St. Louis Cardinals vs Arizona Diamondbacks Pick – 7/19/2025

The St. Louis Cardinals will look to even their three-game series with the Arizona Diamondbacks in Phoenix on Saturday night. The Diamondbacks finally broke through against the Cardinals on Friday night in a 7-3 win. They will look for a repeat performance in this game to further help their NL Wild Card hopes. Continue reading to get my Cardinals vs Diamondbacks prediction for Saturday night in Arizona.

Our Cardinals vs Diamondbacks Pick

  • Pick: Arizona Diamondbacks moneyline
  • Confidence: ★★★★
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Game Snapshot

  • Matchup: St. Louis Cardinals vs Arizona Diamondbacks
  • Date & Time: Saturday, July 19, 2025, at 7:15 p.m. ET
  • Starting Pitchers: Sonny Gray vs Rhyne Nelson
  • Stadium: Chase Field, Phoenix, AZ
  • Broadcast: FOX

Key Storylines

  • Pitching form – St. Louis’ Sonny Gray has a 9-3 record and an ERA of 3.50. He is averaging over a strikeout per inning and is looking to help his team get a much-needed win tonight. Rhyne Nelson of the Diamondbacks has won two straight starts. He is 5-2 on the year with a 3.68 ERA.
  • Bullpen usage – The Diamondbacks have leaned on closer Paul Sewald for late-inning work in recent games. The Diamondbacks have struggled late in games with one of the league’s highest bullpen ERAs. But they did manage to shut the door on the Cardinals last night and will look to do it again tonight.
  • Recent team streaks – Arizona has won two games in a row going into tonight. The Cardinals have dropped three of their last four games entering this one.

Best Player Props

PlayerProp
Sonny GrayOver 5.5 Strikeouts
Eugenio SuarezOver 1.5 Total Bases
  • The Cardinals are 3-1 against the Diamondbacks this season despite losing to them on Friday night.
  • Arizona is 24-25 at home after their win on Friday. St. Louis is 22-27 on the road in 2025.
  • The Cardinals have allowed over five runs in three of their last four games.

St. Louis Cardinals vs Arizona Diamondbacks Model Projection

Score Projection: Arizona Diamondbacks 6 – St. Louis Cardinals 5

Win Probability: Arizona Diamondbacks 53% , St. Louis Cardinals 47%

Final Thoughts

I give a slight edge to the Diamondbacks in this game. The D-Backs should take advantage of the problems that the pitching staff in St. Louis has had of late. And with the Cardinals struggling on the road throughout the season, Arizona should be able to hand St. Louis their second loss in as many days.


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Home MLB Picks St. Louis Cardinals vs Arizona Diamondbacks Pick – 7/19/2025