St. Louis Cardinals vs Arizona Diamondbacks Pick – 7/19/2025
The St. Louis Cardinals will look to even their three-game series with the Arizona Diamondbacks in Phoenix on Saturday night. The Diamondbacks finally broke through against the Cardinals on Friday night in a 7-3 win. They will look for a repeat performance in this game to further help their NL Wild Card hopes. Continue reading to get my Cardinals vs Diamondbacks prediction for Saturday night in Arizona.
Our Cardinals vs Diamondbacks Pick
Pick: Arizona Diamondbacks moneyline
Confidence: ★★★★
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Matchup: St. Louis Cardinals vs Arizona Diamondbacks
Date & Time: Saturday, July 19, 2025, at 7:15 p.m. ET
Starting Pitchers: Sonny Gray vs Rhyne Nelson
Stadium: Chase Field, Phoenix, AZ
Broadcast: FOX
Key Storylines
Pitching form – St. Louis’ Sonny Gray has a 9-3 record and an ERA of 3.50. He is averaging over a strikeout per inning and is looking to help his team get a much-needed win tonight. Rhyne Nelson of the Diamondbacks has won two straight starts. He is 5-2 on the year with a 3.68 ERA.
Bullpen usage – The Diamondbacks have leaned on closer Paul Sewald for late-inning work in recent games. The Diamondbacks have struggled late in games with one of the league’s highest bullpen ERAs. But they did manage to shut the door on the Cardinals last night and will look to do it again tonight.
Recent team streaks – Arizona has won two games in a row going into tonight. The Cardinals have dropped three of their last four games entering this one.
Best Player Props
Player
Prop
Sonny Gray
Over 5.5 Strikeouts
Eugenio Suarez
Over 1.5 Total Bases
Betting Trends & H2H
The Cardinals are 3-1 against the Diamondbacks this season despite losing to them on Friday night.
Arizona is 24-25 at home after their win on Friday. St. Louis is 22-27 on the road in 2025.
The Cardinals have allowed over five runs in three of their last four games.
St. Louis Cardinals vs Arizona Diamondbacks Model Projection
Score Projection: Arizona Diamondbacks 6 – St. Louis Cardinals 5
Win Probability: Arizona Diamondbacks 53% , St. Louis Cardinals 47%
Final Thoughts
I give a slight edge to the Diamondbacks in this game. The D-Backs should take advantage of the problems that the pitching staff in St. Louis has had of late. And with the Cardinals struggling on the road throughout the season, Arizona should be able to hand St. Louis their second loss in as many days.
Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.
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Affiliate Disclosure ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.
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