San Francisco Giants vs St. Louis Cardinals Prediction – 9/7/2025
The San Francisco Giants and St. Louis Cardinals will wrap up their weekend series against each other on Sunday. Playoff hopes still flicker for both clubs going into this matchup. But both teams will need to win games like this one down the stretch to continue to have a chance of making the postseason. For a full breakdown of this game, including my Giants vs Cardinals prediction, continue reading below.
Our Giants vs Cardinals Pick
- Pick: Cardinals -1.5
- Confidence: 3/5
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Game Snapshot
- Head-to-head: San Francisco Giants vs St. Louis Cardinals
- Date & Time: Sunday, September 7, 2025, 2:15 p.m. ET
- Starting Pitchers: Kai-Wei Teng vs Sonny Gray
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: FanDuel Sports Midwest, NBC Sports Bay Area
Key Storylines
- Both of these teams are in desperate need of a win to clinch this series victory. These teams are both between four and six games out of the final Wild Card spot in the National League and they are running out of time to catch up.
- Willson Contreras and Alec Burleson are both set to miss this game for the Cardinals and that could hurt St. Louis’ chances in a big way here.
Starting pitching comparison
- Giants RHP Kai-Wei Teng: Teng is 2-3 with a 7.23 ERA this season. His stuff has potential, but fastball command has been an issue against right-handed lineups.
- Cardinals RHP Sonny Gray: Gray comes into this start at 12-8 with a 4.43 ERA. He has by no means been great this season but he should still give the Cardinals the advantage going into this game.
Recent team streaks
- The Giants had a five-game winning streak snapped with their loss to the Cardinals on Saturday.
- St. Louis has won three of their last four games going into this rubber match with the Giants.
Best Player Props
| Player | Prop |
|---|---|
| Rafael Devers | Over 1.5 Total Bases |
| Sonny Gray | Over 5.5 Strikeouts |
| Kai-Wei Teng | Under 4.5 Strikeouts |
Betting Trends & H2H
- These teams have split the first two games of their season series this year.
- The Cardinals are averaging 2.5 runs per game in their two games against the Giants.
- San Francisco is 37-36 on the road in 2025.
- St. Louis is 40-34 on their home field this season.
Giants vs Cardinals Model Projection
Score Projection: Giants 3 – Cardinals 5
Win Probability: Giants 42%, Cardinals 58%
Final Thoughts
My best bet for this National League matchup is to lay the runline with the St. Louis Cardinals in this contest. The Cards have a huge starting pitching advantage in this game with Sonny Gray on the bump against a struggling Kai-Wei Teng. St. Louis has been solid at home this year and should remain that way to get a win in this game and this series, both of which will help their Wild Card chances coming into the next week of action.
