San Francisco Giants vs San Diego Padres Prediction – 8/20/2025
The San Francisco Giants and San Diego Padres have split the first two games of their four-game series in San Diego. They will face off in a pivotal third game from Petco Park on Wednesday night. San Diego is a slight favorite going into this matchup as they look to help their Wild Card chances while hurting those of their rivals. Continue reading to get my Giants vs Padres prediction from Petco Park.
Our Giants vs Padres Pick
- Pick: Padres Moneyline
- Confidence: 3/5
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Game Snapshot
- Matchup: San Francisco Giants vs San Diego Padres
- Date & Time: Wednesday, August 20, 2025, 9:40 PM EDT
- Starting Pitchers: Landen Roupp (Giants) vs JP Sears (Padres)
- Stadium: Petco Park, San Diego, CA
- Broadcast: MLB Network
Key Storylines
Pitching Matchup
Landen Roupp is 7-6 with a 3.45 ERA and he will take the mound for the Giants tonight. Roupp has been solid for the Giants this year but he faces a tough Padres lineup to work through tonight. JP Sears will get the start for San Diego. Sears has yet to record a decision since joining the Padres from the Athletics and he will look to make his mark here.
Recent Team Streaks
- The Giants had a two-game winning streak snapped in their loss to the Padres last night.
- The Padres’ long losing streak came to a merciful end against the Giants on Tuesday.
Best Player Props
| Player | Prop |
|---|---|
| Jung Hoo Lee | Over 0.5 Home Runs |
| Fernando Tatis Jr. | Over 0.5 Home Runs |
| Landen Roupp | Under 5.5 Strikeouts |
| JP Sears | Over 4.5 Strikeouts |
Betting Trends & H2H
- The Padres hold an 8-3 advantage over the Giants in their season series this year.
- San Diego is 3-1 at home against the Giants this season.
- The Giants are 31-32 on the road in 2025.
- San Diego is 39-21 in their home games for the season.
Giants vs Padres Model Projection
- Score Projection: Padres 5 – Giants 3
- Win Probability: Padres 54%, Giants 46%
Final Thoughts
The Padres have been struggling of late. But they hold the upper hand against the Giants in their meetings this year. San Diego has also been excellent at home and I expect that to continue in this game. I’ll take the Padres to get the win at Petco Park in a huge NL West matchup on Wednesday.
