San Francisco Giants vs San Diego Padres Pick – 8/19/2025
The San Francisco Giants won the opening game of their series against the San Diego Padres on Monday night. They will look for a repeat performance at Petco Park in San Diego on Tuesday. The Padres failed to capitalize on a golden opportunity last night and will try to rebound from that here. Before the action begins in this NL West rivalry game, continue scrolling to get my breakdown of this game and to get my Giants vs Padres prediction.
Our Giants vs Padres Pick
- Pick: Padres -1.5
- Confidence: 5/5
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Game Snapshot
- Matchup: San Francisco Giants vs San Diego Padres
- Date & Time: Tuesday, August 19, 2025, 9:40 PM EDT
- Starting Pitchers: Kai-Wei Teng (Giants) vs Nick Pivetta (Padres)
- Stadium: Petco Park, San Diego, CA
- Broadcast: MLB Network
Key Storylines
Pitching Matchup
The Giants will send rookie right-hander Kai-Wei Teng to the mound to start this contest. He has struggled this season with a 1-2 record and a 9.90 ERA. San Diego has a huge advantage in tonight’s pitching matchup as the Padres will counter with veteran righty Nick Pivetta. Pivetta has a 12-4 record and a 2.87 ERA and will look to drag his team to a much-needed win tonight.
Key Players
- Giants: The duo of Rafael Devers and Heliot Ramos was a force to be reckoned with for the Giants last night. They both went deep in San Francisco’s series-opening win in San Diego.
- Padres: Fernando Tatis Jr. went 0-4 from the leadoff spot for the Padres on Monday and needs to be better in this game.
Recent Team Streaks
- The Giants have won two games in a row and are 5.5 games back of the final NL Wild Card spot.
- San Diego has dropped four straight games going into this contest.
Best Player Props
| Player | Prop | Over/Under |
|---|---|---|
| Jung Hoo Lee | Total Bases | Over 1.5 |
| Xander Bogaerts | RBI | Over 0.5 |
Betting Trends & Head-to-Head
- The Padres hold a 7-3 lead in their season series against the Giants.
- The Giants ended a three-game losing streak at the hands of the Padres last night.
- The Giants have the second-worst runline record in baseball at 52-73 for the season.
- San Diego has the second highest percentage of games that have gone under the total in MLB this season at 57%.
Giants vs Padres Model Projection
- Score Projection: Padres 7 – Giants 3
- Win Probability: Padres 70%, Giants 30%
Final Thoughts
This is as good an opportunity as the Padres will get to bounce back after yesterday’s loss. Pivetta gives San Diego a huge advantage on the mound over a struggling rookie on the opposite side. San Diego can’t afford to drop this game with the Dodgers taking on the lowly Rockies tonight. I’ll lay the runline with San Diego as they should be able to win by two runs or more.
