San Francisco Giants vs Pittsburgh Pirates Pick – 8/6/2025

The San Francisco Giants and Pittsburgh Pirates will close out their three-game series on Wednesday afternoon in Pittsburgh. Each team has claimed one game in this series so far and will look to clinch a series win with a victory in this matchup. Before Pittsburgh and San Francisco play their rubber match at PNC Park, continue reading to get my Giants vs Pirates prediction.

Our Giants vs Pirates Pick

  • Pick: Pittsburgh Pirates moneyline
  • Confidence: ★★★☆☆
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Game Snapshot

  • Matchup: San Francisco Giants at Pittsburgh Pirates
  • Date & Time: Wednesday, August 6, 2025, 12:35 PM ET
  • Starting Pitchers:
    • Giants – Robbie Ray
    • Pirates – Andrew Heaney
  • Stadium: PNC Park, Pittsburgh, PA
  • Broadcast: MLB.tv

Key Storylines

Pitching matchup

San Francisco turns to Robbie Ray on the mound in this game. Ray has had a solid season with a 2.85 ERA. But Ray is winless in his last five starts and will look to end that streak here. Pittsburgh counters with Andrew Heaney on the hill. Heaney has struggled at 5-9 with a 4.89 ERA. He had an ERA of 9.00 in his four starts in July.

Key Players

  • Robbie Ray: Ray is a reliable frontline arm and is capable of high strikeout totals.
  • Andrew Heaney: Heaney has really struggled of late and will need to build confidence in early innings.
  • Oneil Cruz: The Pirates are led in home runs by Cruz. His 18 home runs for the season make him dangerous to Ray and the Giants.
  • Willy Adames: Adames leads the Giants in home runs and RBI this season.

Recent team streaks

  • The Giants won the most recent game in this series and they have won three of their last five.
  • Pittsburgh had a two-game winning streak snapped by San Francisco on Tuesday.

Best Player Props

PlayerProp
Robbie Ray (SF SP)Over 6.5 Ks
Andrew Heaney (PIT SP)Under 5.5 Ks
  • Pittsburgh leads the season series against the Giants by a 4-1 margin.
  • San Francisco is 25-26 in day games this year. Pittsburgh is 22-28 in their day games.
  • Road teams are 4-1 in games played between the Giants and Pirates this year.

Giants vs Pirates Model Projection

Score Projection: Giants 3 – Pirates 4
Win Probability: Giants 41%, Pirates 59%

Final Thoughts

Robbie Ray has cooled off a bit after a very good first half of the season. I expect that trend to continue in this game and for Andrew Heaney to enjoy a little bit of positive regression as well. Pittsburgh should be able to win this game at home and secure the series win against the Giants.


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Home MLB Picks San Francisco Giants vs Pittsburgh Pirates Pick – 8/6/2025