San Francisco Giants vs Milwaukee Brewers Prediction – 8/22/2025
The San Francisco Giants are set to face the Milwaukee Brewers on Friday night at American Family Field in Milwaukee. The Brewers enter this game holding the best record in MLB at 80-48. They are looking to extend their lead in the NL Central while the Giants are aiming to turn their season around and make a push for a Wild Card spot. Continue reading to get my Giants vs Brewers prediction for Friday night.
Our Giants vs Brewers Pick
- Pick: Brewers -1.5
- Confidence: 4/5
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Game Snapshot
- Matchup: San Francisco Giants vs. Milwaukee Brewers
- Date & Time: Friday, August 22, 2025, 8:10 PM ET
- Starting Pitchers: Carson Whisenhunt (Giants) vs. José Quintana (Brewers)
- Stadium: American Family Field, Milwaukee, WI
- Broadcast: FDSWI and NBCS-BA
Key Storylines
Pitching Matchup
José Quintana is 10-4 and has a 3.32 ERA. He will take the mound for the Brewers tonight. The veteran left-hander has been a reliable presence in Milwaukee’s rotation. He has allowed three earned runs or fewer in each of his last five starts.
San Francisco’s Carson Whisenhunt is 1-1 and has a 5.02 ERA. He will make his fourth career MLB start for the Giants tonight after being recalled from AAA Sacramento. Whisenhunt has shown flashes of potential but remains unproven at the major league level. This will be a challenging test against a high-caliber Brewers lineup.
Key Players
- Christian Yelich is the top power hitter for the Brewers this season and he will try to chase the inexperienced Whisenhunt early in this matchup.
- The Giants are very balanced offensively. Their key offensive player sinclude Wilmer Flores and Willy Adames.
Recent Team Streaks
- The Giants have lost three games in a row coming into this series. They lost three out of their four games against the San Diego Padres in their last series.
- Milwaukee lost three out of five games against the Chicago Cubs in their last series. They ended a three-game losing streak with a win in the final game of that five-game set.
Best Player Props
| Player | Prop |
|---|---|
| Christian Yelich | Over 0.5 Home Runs |
| Heliot Ramos | Over 1.5 Total Bases |
| Jose Quintana | Over 5.5 Strikeouts |
Betting Trends & H2H
- San Francisco is 3-1 against the Brewers so far this season.
- The over/under market has gone 2-2 on each side in this season series so far.
- The Giants are 31-34 on the road for the season.
- Milwaukee is 42-20 at home in 2025.
Giants vs Brewers Model Projection
- Score Projection: Giants 4 – Brewers 6
- Win Probability: Giants 40%, Brewers 60%
Final Thoughts
The Brewers enter this game with a significant advantage in both pitching and recent form. Quintana’s experience and the Brewers’ strong home record give them the edge over a Giants team that is relying on an inexperienced starting pitcher. I’ll take Milwaukee to win this game and cover the runline at home as they will continue to showcase that they are the top team in MLB.
