The San Francisco Giants (76-77) head into Dodger Stadium Friday night to face the Los Angeles Dodgers (86-67). The Dodgers enter this game with a three-game lead in the NL West race, while the Giants are 2.5 games back of the final NL Wild Card spot. The Dodgers are favorites in the betting markets, but the Giants are dangerous enough to make this anyone’s game. Here, I break down this NL West matchup and bring you my Giants vs Dodgers prediction for the night.
Our Giants vs Dodgers Pick
- Pick: Giants Moneyline
- Confidence: ★★★☆☆
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Game Snapshot
- Matchup: San Francisco Giants vs Los Angeles Dodgers
- Date & Time: Friday, September 19, 2025, 10:10 PM ET
- Starting Pitchers: Robbie Ray (Giants) vs Clayton Kershaw (Dodgers)
- Stadium: Dodger Stadium, Los Angeles, CA
- Broadcast: Apple TV+
Key Storylines
Pitching matchup
Clayton Kershaw is having a strong season in terms of wins and ERA, and has been successful historically against the Giants. While his strikeout totals are lower than at his peak, he is still incredibly consistent on the mound and will look to finish strong in what he has announced will be his final season.
San Francisco’s Robbie Ray has been solid overall, but his numbers against Los Angeles have been less reliable. In his recent matchups with the Dodgers, Ray has struggled, with a higher ERA and more baserunners allowed than his season average. He will try to change that in a game that feels like a must-win for the Giants on the road.
Recent team streaks
- The Dodgers have won two games in a row coming into this contest, including the opening game of this four-game series.
- San Francisco lost the opening game of this series last night. They have dropped four of their last five games overall.
Best Player Props
| Player | Prop |
|---|---|
| Shohei Ohtani | Over 0.5 Home Runs |
| Clayton Kershaw | Over 5.5 Strikeouts |
| Rafael Devers | Over 0.5 RBI |
Betting Trends & H2H
- The Dodgers are 7-3 against the Giants so far this season.
- The Dodgers have won three games in a row over the Giants.
- San Francisco is 38-40 on the road for the season.
- The Dodgers are 50-28 at home in 2025.
- The Dodgers are 31-14 against NL West opponents in 2025.
- San Francisco is 20-25 against division opponents.
Giants vs Dodgers Model Projection
Score Projection: Giants 5 – Dodgers 4
Win Probability: Dodgers 50%, Giants 50%
Final Thoughts
I think this game is a toss-up, even with the Dodgers being the better team over the course of this season. Robbie Ray will give the Giants a chance to hang around in this game and I think there is value taking the Giants as an underdog in a game that they need to have. I may end up regretting it deeply, but I’ll back the Giants to get the win in one of the games of the night in MLB.
