San Francisco Giants vs Chicago White Sox Prediction – 6/29/2025

On June 29, 2025, the Chicago White Sox will host the San Francisco Giants at Guaranteed Rate Field in an Interleague matchup. The Giants, looking to recover from a Saturday loss to the White Sox, have been performing well this season with a record of 45-38, indicating an above-average campaign. In contrast, the White Sox are struggling significantly, sitting at 27-56, which is among the worst in MLB.

The matchup features two right-handed pitchers: Jonathan Cannon for the White Sox and Justin Verlander for the Giants. Cannon, currently ranked 235th in MLB according to advanced stats, has a Win/Loss record of 2-7 with an average ERA of 4.66. He is projected to pitch only 3.8 innings today, allowing 2.2 earned runs while striking out a mere 3.0 batters. These numbers underscore the difficulties Cannon has faced this season.

Verlander, while not elite, is still a more reliable option. He has a Win/Loss record of 0-5 but maintains an ERA of 4.52. His xERA of 5.07 suggests he has been somewhat fortunate this season. With a projected 5.2 innings pitched and an average of 2.5 earned runs allowed, he stands to have a better outing against a White Sox offense that ranks 30th in team batting average and 30th in overall offensive production.

The Giants' bullpen is notably strong, ranked 2nd in MLB, which could make a significant difference late in the game, especially considering the White Sox rank 27th in their bullpen effectiveness. With the Giants' offense projected for 4.66 runs and the White Sox for only 3.84, San Francisco looks to capitalize on their current form and the White Sox's struggles, making them the favorites in this matchup.

Quick Takes San Francisco Giants:

Among every team playing today, the 2nd-worst outfield defense is that of the San Francisco Giants.

• Defense is an integral part of preventing (or, in this case, allowing) hits and runs.

Jung Hoo Lee is penciled in 6th on the lineup card in this game, which would be a downgrade from his 93% rate of hitting in the top-half of the batting order this season.

• The lower in the order a player bats, the fewer plate appearances he will get and the fewer opportunities he will get to hit the Over for every market. A player who hits lower in the order than he normally does may provide extra value opportunity since the market may be based on him hitting higher.

According to the leading projection system (THE BAT), Patrick Bailey (the Giants's expected catcher in today's matchup) is considered to be an elite pitch framer.

• Pitch framing is a catcher's ability to make a ball look like a strike to the umpire, "stealing" strikes for his pitcher. This leads to more positive outcomes (like strikeouts) and fewer negative ones (like walks or earned runs).

Quick Takes Chicago White Sox:

The leading projection system (THE BAT X) expects Jonathan Cannon to be on a pitch count today, projecting a maximum of 63 pitches.

• A pitcher who is on a pitch count is likely to be pulled from the game earlier, record fewer outs, and generate fewer strikeouts.

Michael A. Taylor has been hot recently, raising his seasonal exit velocity of 90.8-mph to 99.8-mph over the last 7 days.

• Hitting the ball hard increases the chances of either a home run or the ball landing in fair territory for a hit before a fielder can get to it.

The Chicago White Sox bullpen projects as the 5th-worst in MLB, per the leading projection system (THE BAT).

• Most bettors only consider the starting pitcher, but a weak bullpen sneakily creates an easier matchup for the opposing offense and boosts a game's runs.

Game Trends

• The Chicago White Sox have hit the 1st Five Innings (F5) Run Line in 24 of their last 34 games at home (+12.40 Units / 30% ROI)
• The San Francisco Giants have hit the Game Total Under in 37 of their last 63 games (+11.10 Units / 16% ROI)
• Josh Rojas has hit the Total Bases Under in 17 of his last 25 games at home (+8.90 Units / 32% ROI)

San Francisco Giants vs Chicago White Sox Prediction

Predicted Final Score: San Francisco Giants 5.16, Chicago White Sox 4.22

• Date: June 29, 2025
• Venue: Guaranteed Rate Field
• Starting Pitchers:
  • Justin Verlander - Giants
  • Jonathan Cannon - White Sox

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