San Diego Padres vs St. Louis Cardinals Prediction – 7/27/2025
The San Diego Padres and St. Louis Cardinals will face off in the series finale at Busch Stadium on Sunday afternoon. The Cardinals won the first two games of this series before the Padres clawed back a game on Saturday. They will face off in the final game today as both teams look to establish momentum for a playoff push. Continue reading to get our Padres vs Cardinals prediction for Sunday afternoon.
Our Padres vs Cardinals Pick
- Pick: Padres Moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: San Diego Padres vs St. Louis Cardinals
- Date & Time: Sunday, July 27, 2025, 2:15 PM ET
- Starting Pitchers: Stephen Kolek vs Michael McGreevy
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: FDSMW (Cardinals), SDPA (Padres)
Key Storylines
- Pitching matchup: Stephen Kolek comes into this game at 3-5 and a 4.28 ERA for the Padres. He will face Michael McGreevy of the Cardinals. McGreevy is 2-1 with a 3.49 ERA on the year. McGreevy’s control will be a factor in this game. He has allowed just three walks in 28.1 innings this year.
- Key Players: Manny Machado leads the Padres in batting average, home runs, and RBI. Willson Contreras has 14 home runs and 61 RBI to lead the Cardinals in both of those statistical categories this year.
- Recent team streaks: The Padres ended an extended losing streak with their win over the Cardinals on Saturday. The Cardinals are 2-3 in their last five games and they had a two-game winning streak snapped on Saturday.
Best Player Props
| Player | Prop |
|---|---|
| Manny Machado | Over 0.5 Home Runs |
| Stephen Kolek | Over 4.5 Strikeouts |
Betting Trends & H2H
- The Cardinals hold a 2-1 lead in the season series between these teams.
- After this series finale, these teams will play three more times in August.
- The under has gone 2-1 in the matchups between these teams this year.
Padres vs Cardinals Model Projection
- Score Projection: Padres 5 – Cardinals 4
- Win Probability: Padres 54%, Cardinals 46%
Final Thoughts
The Padres have fought back nicely after dropping the first two games of this series against the Cardinals. I expect the Padres to continue fighting back to even this series at two games apiece with a win here in what should be a relatively low-scoring game in St. Louis.
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