San Diego Padres vs St. Louis Cardinals Prediction – 7/25/2025
The San Diego Padres will visit Busch Stadium to take on the St. Louis Cardinals on Friday night. The Cardinals won an exciting series opener between these teams last night. They will aim for a repeat performance at home at the expense of their opponents from the NL West. Be sure to keep reading to get my Padres vs Cardinals prediction before first pitch in this game.
Our Padres vs Cardinals Pick
- Pick: San Diego Padres moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: San Diego Padres at St. Louis Cardinals
- Date & Time: Friday, July 25, 2025, 7:15 PM ET
- Starting Pitchers: Nick Pivetta (SD) vs. Miles Mikolas (STL)
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: PDTV / FDMW
Key Storylines
- Nick Pivetta has emerged as the ace of the Padres’ rotation. He is 10-2 with a 2.81 ERA on the season. He has been nothing short of phenomenal and will look to stay that way here.
- The Cardinals have an inconsistent pitcher on the mound to start this game in Miles Mikolas. Mikolas is 5-7 and has a sky-high 5.20 ERA on the year.
- St. Louis is missing some key contributors such as Lars Nootbaar and Nolan Gorman from their lineup right now.
- The Padres have lost three games in a row coming into this contest. That includes last night’s 9-7 loss to the Cardinals.
- The Cardinals bounced back from a series loss to the Colorado Rockies by beating the Padres last night. They are 2-2 in their last four games.
Best Player Props
| Player | Prop |
|---|---|
| Manny Machado | Over 0.5 Home Runs |
| Nick Pivetta | Over 5.5 Strikeouts |
Betting Trends & H2H
- Last 5 games: Both teams are 2-3 in their last five games coming into this matchup.
- Head-to-head: Yesterday was the only game played between these teams so far this year. The Cardinals lead the season series 1-0.
- Yesterday’s game between these teams went well over the total.
Padres vs Cardinals Model Projection
Score Projection: San Diego 5 – St. Louis 3
Win Probability: San Diego 57%, St. Louis 43%
Final Thoughts
San Diego is struggling coming into this National League matchup with the Cardinals. But they have a significant starting pitching edge in this game. Nick Pivetta is pitching better than just about everyone in the majors right now. I think that he will help the Padres to get a much-needed win on the road over the Cardinals in this contest.
