San Diego Padres vs San Francisco Giants Pick – 8/13/2025
The San Diego Padres have dominated their three-game series against the San Francisco Giants so far. San Diego’s pitching staff has mowed down Giants hitters over the last two days. They will look to do so again on Wednesday. Before the final game of this three-game series from San Francisco, you can continue reading to get my Padres vs Giants prediction.
Our Padres vs Giants Pick
- Pick: San Diego Padres Moneyline
- Confidence: 5/5
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Game Snapshot
- Matchup: San Diego Padres vs San Francisco Giants
- Date & Time: Wednesday, August 13, 2025, 3:45 PM ET
- Starting Pitchers: Nick Pivetta (11-4, 2.94 ERA) vs Kai-Wei Teng (1-1, 5.40 ERA)
- Stadium: Oracle Park, San Francisco, CA
- Broadcast: NBC Bay Area, SDPA
Key Storylines
- Pitching matchup: The Padres have the advantage in the starting pitching matchup today. Nick Pivetta brings reliable performance and a sub-3.00 ERA to the hill. Kai-Wei Teng has worked just 8.1 innigns this season and has a shaky 5.40 ERA. That disparity sets the tone clearly in favor of San Diego’s righty.
- Key Players: The Padres’ bullpen will once again be the key to this game. The Giants have scored just one run ine ach of the first two games of this series. The Padres could close out a series sweep of their rivals if San Diego can close the door with their bullpen again today.
- Recent team streaks: These teams are moving in opposite directions heading into this series finale. The Padres have won four games in a row and the Giants have lost four straight games going into Wednesday’s matchup.
Best Player Props
| Player | Prop |
|---|---|
| Manny Machado (SD) | Over 1.5 Total Bases |
| Willy Adames (SF) | Over 1.5 Total Bases |
| Nick Pivetta (SD) | Over 5.5 Strikeouts |
Betting Trends & H2H
- The Padres are 6-2 against the Giants so far this season.
- The Padres are 27-15 in day games so far this year. The Giants are 25-27 in their daytime starts.
- San Francisco has dropped to 29-30 at home for the season after losing the first two games of this series on their home field.
- San Diego is still below .500 on the road at 30-32.
Padres vs Giants Model Projection
Score Projection: San Diego Padres 5 – San Francisco Giants 3
Win Probability: Padres 57%, Giants 43%
Final Thoughts
The starting pitching matchup in this game should give the Padres the advantage they need to lock up a series sweep against the Giants. Nick Pivetta has been one of the best pitchers in the National League throughout this season. I expect that to continue with a strong showing in this game. I’ll take the Padres to win on the road and take a third straight against San Francisco.
