The San Diego Padres and Chicago White Sox will wrap up their weekend series in Chicago on Sunday afternoon. The Padres (84–71) got a much-needed win on Saturday at Rate Field and will look to take down the White Sox (58–97) again today. San Diego’s postseason hopes are hanging in the balance late in the regular season. Before first pitch from Chicago, continue reading to get my Padres vs White Sox prediction.
Our Padres vs White Sox Pick
- Pick: Padres -1.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: San Diego Padres vs Chicago White Sox
- Date & Time: Sunday, September 21, 2025, 2:10 PM ET
- Starting Pitchers: Michael King (Padres) vs Sean Burke (White Sox)
- Stadium: Rate Field, Chicago, IL
- Broadcast: CHSN and SDPA
Key Storylines
Pitching matchup
Michael King has been solid this season, with a 3.84 ERA and a WHIP of 1.17 in 65.2 innings pitched. He offers decent strikeout numbers and limits damage when he’s on top of his game. Sean Burke has struggled more. His 4-10 record and 4.29 ERA reflect inconsistency and more frequent damage allowed than King. The metrics favor King to hold things together more effectively.
Recent team streaks
The Padres have lost 3 of their last 5 games, but they snapped a two-game slide with a strong showing Saturday. They remain in the thick of the NL wild‐card race and have more at stake going into this game. Chicago has lost seven of their last eight games and they could fall to 40 games below .500 with a loss in this contest.
Best Player Props
| Player | Prop Type | Pick |
|---|---|---|
| Manny Machado | Home Runs | Over 0.5 |
| Lenyn Sosa | Home Runs | Over 0.5 |
| Sean Burke | Strikeouts | Under 5.5 |
| Michael King | Strikeouts | Over 5.5 |
| Fernando Tatis Jr. | Total Bases | Over 1.5 |
Betting Trends & H2H
- These teams are 1-1 against each other this season.
- This is the final regular-season meeting between the Padres and White Sox.
Padres vs White Sox Model Projection
Score Projection: Padres 6 ‒ White Sox 3
Win Probability: Padres ~63%, White Sox ~37%
Final Thoughts
This game leans strongly toward the Padres from a betting standpoint. King’s superior form, the White Sox’s struggles, and the Padres’ sense of urgency in the standings all point to San Diego being the side to back in this game. I recommend laying the runline with the Padres here, as they should win this key contest by two runs or more on the road.
