The San Diego Padres (83-71) will take on the Chicago White Sox (58-96) at Rate Field in Chicago on Saturday night. After a 4-3 loss on Friday, the Padres will look to rebound against a White Sox team that ended a six-game losing streak with their victory. Can San Diego avoid another hit to their NL West title hopes? Continue reading to get my Padres vs White Sox prediction for Saturday night.
Our Padres vs White Sox Pick
- Pick: Padres -1.5
- Confidence: 3/5
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Game Snapshot
- Matchup: San Diego Padres vs. Chicago White Sox
- Date & Time: Saturday, September 20, 2025, 7:10 PM EDT
- Starting Pitchers: Yu Darvish vs Yoendrys Gomez
- Stadium: Rate Field, Chicago, IL
- Broadcast: MLB.tv
Key Storylines
Pitching Matchup
Yu Darvish (4-5, 5.63 ERA) is set to start for the Padres. Despite a challenging season, Darvish brings playoff experience and a high strikeout rate. In his last outing, he allowed four runs over six innings and Darvish will look to bounce back from his recent struggles tonight.
Yoendrys Gómez (3-2, 4.91 ERA) will take the mound for the White Sox. Gómez has shown flashes of potential but has struggled with consistency. His ability to limit walks and keep the ball in the park will be crucial against a potent Padres lineup. But 27 walks in 51.1 innings of work is concerning stuff from Gomez.
Recent Team Trends
- Padres: The Padres have lost three of their last five games, including a 4-3 defeat to the White Sox on Friday. They are 83-71 on the season and are fighting for playoff positioning in the National League.
- White Sox: Chicago snapped a six-game losing streak with their win on Friday. They are 58-96 on the season and have struggled both offensively and on the mound.
Best Player Props
| Player | Prop Type | Line |
|---|---|---|
| Manny Machado | Home Runs | Over 0.5 |
| Luis Arraez | Total Bases | Over 1.5 |
| Lenyn Sosa | Hits | Over 1.5 |
| Andrew Benintendi | RBIs | Over 0.5 |
Betting Trends & H2H
- Chicago holds a 1-0 lead in the season series against San Diego.
- The first game of this series had seven total runs scored and stayed under the total.
Padres vs White Sox Model Projection
- Score Projection: Padres 5 – White Sox 3
- Win Probability: Padres 65%, White Sox 35%
Final Thoughts
While the White Sox ended their losing streak on Friday, the Padres remain the stronger team overall. With Darvish on the mound and a lineup featuring Machado and Arraez, San Diego has the tools to secure a comfortable victory. Betting on the Padres to cover the runline as a favorite looks like a solid value to me as they should bounce back from last night’s loss.
