New York Yankees vs St. Louis Cardinals Pick – 8/15/2025
The two most successful franchises in MLB history will open a weekend series on Friday night as the New York Yankees visit the St. Louis Cardinals. Both teams are involved in heated Wild Card races in their respective leagues and are looking for some significant victories this weekend. Before first pitch from Busch Stadium on Friday night, you can continue reading to get my Yankees vs Cardinals prediction.
Our Yankees vs Cardinals Pick
- Pick: Cardinals moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: New York Yankees vs St. Louis Cardinals
- Date & Time: Friday, August 15, 2025, 8:15 PM ET
- Starting Pitchers: Luis Gil (0–1, 7.27 ERA) vs Andre Pallante (6–9, 4.95 ERA)
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: FDSMW, YES Network
Key Storylines
Pitching Matchup
Yankees starter Luis Gil is making just his third start after missing most of the season due to injury. He had a rough debut before steadying the ship against the Houston Astros. Gil has allowed 11 hits in 8.2 innings of work and has a 7.27 ERA. The Cardinals will counter with Andre Pallante. He has had mixed results with a 6-9 record and a 4.95 ERA this season. Gil’s upside is high but he is still hard to trust given how little he has pitched this season. Pallante has fared better at home but any pitcher is vulnerable against the Yankees’ lineup.
Goldschmidt Returns to St. Louis
Paul Goldschmidt was one of the best players in baseball for a period of his time with the St. Louis Cardinals. The question going into this game is whether or not he is available to suit up for the Yankees. Goldschmidt is dealing with a knee injury and could miss this game after being held out of Wednesday’s matchup with the Minnesota Twins.
Recent Team Streaks
- The Yankees won two out of their three games against the Twins in their series prior to this one.
- The Cardinals have lost two games in a row and dropped two out of three to the Colorado Rockies in a shocking series result.
Best Player Props
| Player | Prop Type | Pick |
|---|---|---|
| Aaron Judge | Home runs | Over 0.5 |
| Luis Gil | Strikeouts | Over 4.5 |
| Giancarlo Stanton | Total bases | Under 1.5 |
Betting Trends & H2H
- This is the first game of the season series between these teams this season.
- New York is 20-22 in interleague matchups this season.
- The Cardinals are 19-17 against American League opponents for the year.
Yankees vs Cardinals Model Projection
Score Projection: Cardinals 5 – Yankees 4
Win Probability: Cardinals 52%, Yankees 48%
Final Thoughts
Luis Gil gave up two runs against the Houston Astros in his last start. That was an encouraging sign, but I still need to see him pitch well over a larger sample size to trust him against quality competition. I will bet on there being some regression from Gil in this game and for the Cardinals to get a win as a home underdog on Friday night.
