New York Yankees vs Minnesota Twins Pick – 9/15/2025

The New York Yankees and Minnesota Twins will face off at Target Field on Monday night. The Yankees come into this series opener in the top Wild Card spot in the American League and they will try to move closer to the top spot in the AL East against a Twins team that has been eliminated from playoff contention. Here, I break down this American League matchup and bring you my Yankees vs Twins prediction for this contest.

Our Yankees vs Twins Pick

• Pick: Yankees -1.5
• Confidence: 4/5
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4.5/5

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Game Snapshot

• Matchup: New York Yankees vs Minnesota Twins
• Date & Time: Monday, September 15, 7:40 p.m. ET
• Starting Pitchers: Carlos Rodón vs Simeon Woods Richardson
• Stadium: Target Field, Minneapolis, MN
• Broadcast: YES in New York, Twins.TV in Minnesota

Key Storylines

• Form and health: New York just took a series at Boston with Jazz Chisholm Jr. and Aaron Judge doing damage. Minnesota’s coming off another series loss and they are banged up at the catcher spot going into this matchup.
• The Yankees are fighting for their postseason lives late in the season. They are 2.5 games clear in the AL Wild Card race and four games back of the Toronto Blue Jays in the AL East standings. They will look to get closer to the playoffs with a win here.
• Minnesota is one of two American League teams that has been eliminated from playoff contention. They are playing for pride and to play the role of spoiler late in the year.

Pitching matchup

• Carlos Rodón will get the start for the Yankees. He is 16-8 with a 3.11 ERA over 176.1 innings pitched. He threw seven dominant innings against Minnesota on August 12 and has had multiple quality starts in September already.
• Simeon Woods Richardson is on the bump for the Twins tonight. Woods Richardson is 6-4 and has a 4.58 ERA over 94.1 innings of work. His fly-ball heavy metrics could be problematic against a New York order that ranks near the top of the league in homers and slugging percentage.

Recent team streaks

• The Yankees had a three-game winning streak snapped with their loss to the Red Sox on Sunday night.
• Minnesota has lost two games in a row and four of their last five.

Best Player Props

Betting Trends & H2H

• The Yankees hold a 2-1 lead in the season series against the Twins in 2025.
• New York took the first two meetings between these teams in August and Minnesota answered with a 4-1 win in the finale.
• New York is 39-35 on the road this season.
• Minnesota is 36-38 in their home games in 2025.

Yankees vs Twins Model Projection

Score Projection: Yankees 5 – Twins 3

Win Probability: Yankees 63%, Twins 37%

Final Thoughts

I recommend laying the runline with the Yankees in this game. Rodon gives New York a distinct starting pitching advantage and I think that the Yankees lineup will get to Woods Richardson early on. I’ll go with New York to take the first game of this series and help their chances both in their division race and for locking up a Wild Card spot.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.