New York Yankees vs Houston Astros Pick – 9/3/2025

The New York Yankees and Houston Astros will play the second game of a three-game series on Wednesday night in Houston. The Yankees dominated the opening game of this series and caused some major frustration for Astros starter Framber Valdez. New York will look to take a second straight from Houston here, while the Astros aim to even up the series. Continue reading to get my Yankees vs Astros prediction for Wednesday night.

Our Yankees vs Astros Pick

  • Pick: Yankees Moneyline
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Game Snapshot

  • Matchup: New York Yankees vs. Houston Astros
  • Date & Time: Wednesday, September 3, 2025, 8:10 PM ET
  • Starting Pitchers: Will Warren (NYY) vs Jason Alexander (HOU)
  • Stadium: Daikin Park, Houston, TX
  • Broadcast: MLB Network, Prime Video

Key Storylines

Pitching Matchup

Will Warren (8–6, 4.30 ERA) will take the mound for the Yankees. The 25-year-old rookie has been a revelation this year. He has 19 starts allowing two earned runs or fewer. That is the second-most by a Yankees rookie in a single season. His consistency and ability to limit damage make him a reliable option in high-stakes games.

Opposing Warren is Jason Alexander (4–1, 4.61 ERA) for the Astros. Alexander has been effective in a limited role. But his 4.61 ERA suggests that he could struggle against potent lineups. Alexander did throw six shutout innings against the Yankees earlier in the year and will aim for a repeat performance tonight.

Key Players

  • Aaron Judge (NYY): The reigning MVP is having another stellar season. He is leading the Yankees with a .325 batting average and 43 home runs. His presence in the lineup is a constant threat to opposing pitchers.
  • Yordan Álvarez (HOU): Álvarez’s power bat is a difference maker for the Astros’ offense. His ability to drive in runs will be vital for Houston’s success against Warren.

Recent Team Streaks

  • The Yankees have won four of their last five games coming into this rivalry game against the Stros.
  • Houston has dropped three of its last four games and is three games ahead of the Seattle Mariners in the AL West race.

Best Player Props

PlayerProp
Aaron JudgeOver 0.5 Home Runs
Yordan ÁlvarezOver 0.5 Home Runs
Will WarrenOver 17.5 Outs Recorded
  • The season series between these teams is tied 2-2 on the year.
  • Road teams are 3-1 in this season series thus far.
  • Every game between these teams in 2025 has had nine runs or fewer.

Yankees vs Astros Model Projection

  • Score Projection: Yankees 5 – Astros 4
  • Win Probability: Yankees 55%, Astros 45%

Final Thoughts

I am going to go with the Yankees to beat the Astros for the second game in a row. New York’s power bats should be a lot better than they were the first time they faced Jason Alexander. I’ll bank on Judge to go deep in this game and for the Yankees to get another important win for their playoff chances.


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Home MLB Picks New York Yankees vs Houston Astros Pick – 9/3/2025