Minnesota Twins vs Los Angeles Dodgers Pick – 7/21/2025

The Minnesota Twins travel to Dodger Stadium on Monday night to take on the Los Angeles Dodgers in the opener of a three-game interleague series. The Dodgers are sitting atop the National League standings. But they have struggled of late and will turn to superstar Shohei Ohtani on the mound and at the plate here. Before the first pitch of this contest, you can keep reading to get my Twins vs Dodgers prediction for the night.

Our Twins vs Dodgers Pick

• Pick: Minnesota Twins Moneyline
• Confidence: ★★★★
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Game Snapshot

• Matchup: Minnesota Twins at Los Angeles Dodgers
• Date & Time: Monday, July 21, 2025, 10:10 PM ET
• Starting Pitchers: Shohei Ohtani vs David Festa
• Stadium: Dodger Stadium, Los Angeles, CA
• Broadcast: SportsNet LA

Key Storylines

• Ohtani On the Mound: Shohei Ohtani is coming off three scoreless innings in San Francisco in his last start. He will aim to stretch deeper into this game with Dustin May behind him to eat up innings if need be.
• Festa’s Road Struggles: David Festa has allowed 12 earned runs over his last two starts. He will face a potent Dodgers lineup that will limit his margin for error in this game.
• Twin Power Surge: Royce Lewis crushed two home runs in Friday’s win over Colorado and leads Minnesota with 17 on the season.
• Bullpen Depth: Both teams are in the bottom 10 in MLB in bullpen ERA. Los Angeles has the luxury of putting in May if Ohtani goes out early. But we could see late scoring from both sides in this matchup.
• Recent Runs: The Dodgers have lost three straight games. The Twins have lost three of their last four.

Best Player Props

Betting Trends & H2H

• This is the first meeting between these teams this season. They are scheduled for just three games against each other during the regular season.
• The Dodgers are 33-20 at home on the year. Minnesota is 20-31 on the road.
• The Dodgers are 3-2 in games that Ohtani has pitched so far this season.

Twins vs Dodgers Model Projection

Score Projection: Minnesota 5 – Los Angeles 4

Win Probability: Minnesota 50%, Los Angeles 50%

Final Thoughts

The Dodgers are not playing their best baseball of late. They also aren’t likely to see Ohtani go more than four or five innings in this contest. Those things could add up to a win for the Twins in this game. At the very least, I think Minnesota is worth a shot on the moneyline in this interleague series opener on the West coast.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.