Minnesota Twins vs Colorado Rockies Prediction – 7/19/2025

The Minnesota Twins will play the second game of a three-game road series against the Colorado Rockies in Denver on Saturday night. The Twins will look to rebound after dropping the series opener in surprising fashion. Colorado will look to build on Friday’s win but will need to overcome a pitching disadvantage to do so. Here, I break down this interleague matchup in Major League Baseball and make my Twins vs Rockies prediction for Saturday.

Our Twins vs Rockies Pick

• Pick: Minnesota Twins -1.5
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Minnesota Twins vs Colorado Rockies
• Date & Time: Saturday, July 19, 202,5 at 8:10 PM ET
• Starting Pitchers: Zebby Matthews vs Antonio Senzatela
• Stadium: Coors Field, Denver, CO
• Broadcast: COLR and MNNT

Key Storylines

1. Pitching duel – Zebby Matthews is 1-1 this season with a 5.21 ERA. He seeks his third quality start in four turns after allowing two runs over six innings in his last outing. Antonio Senzatela is 3-13 and has a 6.60 ERA. He looks to rebound and deliver the Rockies a second straight upset win over the Twins.
2. Coors Field factor – Colorado’s thin air often leads to high-scoring games. Twins hitters have struggled on the road but have enough pop to recover in this game if they can get to Senzatela early on.
3. Series momentum – The Rockies grabbed Friday’s opener by striking early and holding on late. The Twins need a swift response to avoid falling four games under .500 for the season.
4. Recent streaks – The Twins have lost two games in a row to the Pirates and Rockies coming into this game. The Rockies snapped a two-game losing streak with their win on Friday night.

Best Player Props

Betting Trends & H2H

• The Rockies are 1-0 against the Twins so far this season.
• The Twins have scored under five runs in four of their last five games.
• Minnesota is 19-30 on the road this year. The Rockies are 11-36 at home.

Minnesota Twins vs Colorado Rockies Model Projection

Score Projection: Twins 5 – Rockies 3

Win Probability: Twins 69% Rockies 31%

Final Thoughts

I expect the Twins to bounce back with a win tonight at Coors Field. Matthews should keep Colorado’s offense in check early and Minnesota’s lineup features enough pop to score against Senzatela. I prefer laying the runline with the Twins in this situation rather than laying a ton of juice with them on the moneyline.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.