The Milwaukee Brewers (94-60) will face the St. Louis Cardinals (75-79) at Busch Stadium on Saturday night. The Brewers are aiming to clinch the NL Central title, while the Cardinals look to play spoiler. Before these division rivals meet in St. Louis, you can keep reading to get my Brewers vs Cardinals prediction for tonight’s action.
Our Brewers vs Cardinals Pick
- Pick: Milwaukee Brewers Moneyline
- Confidence: 4/5
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Game Snapshot
- Matchup: Milwaukee Brewers vs St. Louis Cardinals
- Date & Time: Saturday, September 20, 2025, 7:15 PM ET
- Starting Pitchers: Chad Patrick (MIL) vs. Miles Mikolas (STL)
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: FanDuel Sports Network Wisconsin, FanDuel Sports Network Midwest
Key Storylines
Pitching Matchup
Chad Patrick (MIL) enters with a 3-8 record and a 3.64 ERA. Despite a modest win-loss record, he has demonstrated solid strikeout ability, averaging 9.4 strikeouts per nine innings. Miles Mikolas (STL) enters this game with an 8-10 record and a 4.80 ERA. He has struggled with consistency and has allowed 1.6 home runs per nine innings. Patrick’s strikeout output and Mikolas’ susceptibility to the long ball could influence the game’s outcome.
Key Players
For the Brewers, Christian Yelich leads the team with 100 RBI and 29 home runs. Sal Frelick is returning to the top of the order and has a .296 batting average. The Cardinals’ offense has been highlighted by Nolan Arenado’s recent return and Lars Nootbaar’s contributions. They will aim to support Mikolas on the mound.
Recent Team Streaks
The Brewers had a three-game winning streak snapped by the Cardinals in their most recent game. The Cardinals have won three of their last five games and they will look to deny the Brew Crew a division title this weekend.
Best Player Props
| Player | Prop |
|---|---|
| Christian Yelich | Over 0.5 Home Runs |
| Sal Frelick | Over 1.5 Total Bases |
| Chad Patrick | Over 5.5 Strikeouts |
Betting Trends & H2H
- Both teams are 3-2 over their last five games.
- The Brewers hold a 6-5 lead in the regular-season series between these teams.
- The Cardinals have won two straight games over the Brewers this season.
Brewers vs Cardinals Model Projection
- Score Projection: Brewers 5 – Cardinals 3
- Win Probability: Brewers 57.6%, Cardinals 42.4%
Final Thoughts
The Milwaukee Brewers should have the inside track to win this game on the road. Milwaukee is better offensively and they have the advantage in the starting pitching department as well. I expect the Brew Crew to move closer to the NL Central title, or for them to clinch it outright by the end of the weekend. They will get a win on the road here to end their mini-losing streak against the Cards.
