Milwaukee Brewers vs Seattle Mariners Pick – 7/21/2025

The Milwaukee Brewers visit T-Mobile Park to face the Seattle Mariners on Monday night. Both clubs enter this contest with postseason aspirations following strong first halves to the season. The Brewers are playing some of the best baseball in the league right now. It will be up to the Mariners to find a way to put a stop to that at home. Here, I break down this interleague contest and make my Brewers vs Mariners prediction for Monday’s game.

Our Brewers vs Mariners Pick

• Pick: Milwaukee Brewers moneyline
• Confidence: ★★★☆☆
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Game Snapshot

• Matchup: Milwaukee Brewers vs Seattle Mariners
• Date & Time: Monday, July 21, 2025 at 9:40 PM ET
• Starting Pitchers: Brandon Woodruff vs George Kirby
• Stadium: T-Mobile Park, Seattle, WA
• Broadcast: ROOT Sports NW and FDSWI

Key Storylines

• Pitching form: Brandon Woodruff has looked good since starting his season late due to injury. Woodruff has a 1-0 record and a 2.61 ERA. This game will be a significant test for him in his comeback. George Kirby of the Mariners has rebounded from early struggles. He is 4-4 and has a 4.50 ERA. But you would expect him to continue to rein in that ERA here.
• Bullpen usage: Milwaukee’s relievers have a slightly higher ERA than those of the Mariners do. Still, both teams have bullpen ERAs just under 4.00 for the season. We should see an evenly-matched bullpen battle in this contest.
• Recent team streaks: The Brewers are riding a 10-game win streak. Mariners have won four of their last five but had their winning streak snapped by the Houston Astros on Sunday.

Best Player Props

Betting Trends & H2H

• This is the first of three scheduled meetings between these teams for the season.
• Milwaukee has been much better in night games. The Brewers are 32-22 at night this season. Seattle is 29-32 at night.
• The Brewers are 26-23 on the road in 2025. The Mariners are 27-22 at home.

Brewers vs Mariners Model Projection

Score Projection: Milwaukee 5 – Seattle 3

Win Probability: Milwaukee 56% – Seattle 44%

Final Thoughts

Brandon Woodruff has been very good for the Brewers since making his delayed debut this season. In this game, I will take Woodruff and the Brewers to get the job done on the road, as I have been very impressed with the play of the Brewers on both sides of the All-Star break.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.

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Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.