The San Diego Padres and Milwaukee Brewers will meet on Tuesday night at Petco Park in San Diego. The Padres clinched a postseason berth in dramatic fashion with an 11th-inning walk-off win over these same Brewers on Monday. Milwaukee has already locked up the NL Central and is jockeying for the top seed in the National League. Before the first pitch from San Diego, continue reading to get my Brewers vs Padres prediction for Tuesday’s game.
Our Brewers vs Padres Pick
- Pick: Padres Moneyline
- Confidence: 3/5
Game Snapshot
- Matchup: San Diego Padres vs Milwaukee Brewers
- Date & Time: Tuesday, September 23, 2025, 9:40 PM ET
- Starting Pitchers: Bruce Zimmermann (Brewers) vs Randy Vásquez (Padres)
- Stadium: Petco Park, San Diego, CA
- Broadcast: SDPA and FDSWI
Key Storylines
- Pitching matchup: Randy Vásquez enters tonight’s start with a 5-7 record, a 3.94 ERA, and a 1.36 WHIP this season. Bruce Zimmermann comes in as the Brewers’ starter for this one. He has not pitched in a major league game since 2023 and will look to make an immediate impact for the Brewers in this contest.
- Key Players: Christian Yelich remains a steady bat for Milwaukee. He has over 100 RBI and close to 30 home runs. Brice Turang leads the Brewers in hits and will also be called upon to deliver if Milwaukee is going to win tonight. Manny Machado and Luis Arraez are standout threats for the Padres. Fernando Tatis Jr. is day-to-day and his status is up in the air for this huge matchup between National League opponents.
- Recent team streaks: The Padres have won three games in a row after Monday’s win over the Brewers. Momentum is on their side, especially at home. The Brewers, despite having locked up their division, have dropped three of their last four games and they will look to turn things around before the postseason begins.
Best Player Props
| Player | Prop | Over/Under |
|---|---|---|
| Christian Yelich | Total Bases | Over 1.5 |
| Luis Arraez | Hits | Over 1.5 |
| William Contreras | Home Runs | Over 0.5 |
Betting Trends & H2H
- San Diego has won three of the four games they have played against the Brewers this season.
- San Diego has won two games in a row over the Brew Crew.
- The last three games played between these teams have all been decided by one run apiece.
Brewers vs Padres Model Projection
- Score Projection: Brewers 4 – Padres 5
- Win Probability: Brewers 49%, Padres 51%
Final Thoughts
This game should be very close, just as the other recent games between these teams have been. But I think the Padres have the advantage here, thanks in large part to the starting pitching situation for the Brewers. Zimmerman hasn’t pitched at this level in a long time and the Padres should take advantage of that. I will go with San Diego to get the win at home in what should be a good game on Tuesday night.
