Milwaukee Brewers vs Pittsburgh Pirates Prediction – 9/7/2025

The Milwaukee Brewers and Pittsburgh Pirates will wrap up their three-game set on Sunday at PNC Park. Milwaukee sends electric rookie right-hander Jacob Misiorowski to the mound against Pittsburgh’s Bubba Chandler. Milwaukee has taken the first two games of this series and will look to secure a sweep today. Before the first pitch from Pittsburgh, continue reading to get my Brewers vs Pirates prediction for the day.

Our Brewers vs Pirates Pick

  • Pick: Brewers moneyline
  • Confidence: 4/5
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Game Snapshot

  • Matchup: Milwaukee Brewers vs Pittsburgh Pirates
  • Date & Time: Sunday, September 7, 1:35 PM ET
  • Starting Pitchers: Jacob Misiorowski vs Bubba Chandler
  • Stadium: PNC Park, Pittsburgh, PA
  • Broadcast: MLB.tv

Key Storylines

  • Milwaukee’s offense remains a difference-maker. They rank near the top of the league in runs and on-base percentage.
  • Pittsburgh’s recent sweep over Los Angeles injected confidence into the Pirates but their season-long offensive output still lags.
  • Misiorowski already authored a standout effort against Pittsburgh in June, outpitching Paul Skenes.

Pitching matchup

Jacob Misiorowski brings premium velocity and swing-and-miss stuff. His record entering Sunday is 4-2 with a 4.50 ERA across 48.0 innings. The rookie’s earlier outing versus Pittsburgh was a blueprint for success. Misiorowski threw five scoreless innings with eight strikeouts in late June. Bubba Chandler will begin this game on the mound for Pittsburgh. He is 2-0 with a 2.25 ERA in 12 innings of work so far in 2025.

Recent team streaks

  • The Brewers have won two straight games and three of their last four.
  • Pittsburgh has dropped two games in a row entering today’s action.

Best Player Props

PlayerProp TypeSuggested Play
Christian YelichTotal BasesOver 1.5
Jacob MisiorowskiStrikeoutsOver 5.5
Oneil CruzHome RunOver 0.5
  • The Brewers lead their season series against the Pirates by a 9-3 margin.
  • Both games in this series so far have seen seven runs or fewer.
  • This is the final game of the regular-season series between Milwaukee and Pittsburgh in 2025.
  • Milwaukee enters this game with a 42-29 record on the road.
  • Pittsburgh is 42-32 at home for the year despite their overall struggles to win games.

Brewers vs Pirates Model Projection

Score Projection: Brewers 5 – Pirates 3

Win Probability: Brewers 58%, Pirates 42%

Final Thoughts

The Brewers should be able to get the win on the road to finish a three-game sweep of the Pittsburgh Pirates. Misiorowski has looked very good for the most part this year and he should be able to outperform an unknown quantity in Bubba Chandler. Look for Milwaukee to continue to move closer to locking up the best record in baseball as they should be able to get a win in this contest from Pennsylvania.


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Home MLB Picks Milwaukee Brewers vs Pittsburgh Pirates Prediction – 9/7/2025