Milwaukee Brewers vs Chicago Cubs Prediction – 8/21/2025
The Chicago Cubs went into this week’s five-game series against the Milwaukee Brewers in need of wins. They have got those wins so far as they have won three of the first four games of the series. These NL Central rivals will meet one more time to close out this series from Wrigley Field in a game with huge implications in the division race. Before the first pitch on Thursday afternoon, continue reading to get my Brewers vs Cubs prediction.
Our Brewers vs Cubs Pick
- Pick: Cubs Moneyline
- Confidence: 4/5
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Game Snapshot
- Matchup: Milwaukee Brewers vs Chicago Cubs
- Date & Time: Thursday, August 21, 2025, 2:20 p.m. ET
- Starting Pitchers:
- Brewers – Quinn Priester (11–2, 3.48 ERA)
- Cubs – Shota Imanaga (8–5, 3.06 ERA)
- Stadium: Wrigley Field, Chicago, IL
- Broadcast: MLB Network
Key Storylines
Pitching matchup
The Cubs send Shota Imanaga to the mound. He enters this contest with a 3.06 ERA and is aiming to halt the Brewers’ powerful offense. Milwaukee will go with Quinn Priester on the hill. He has an 11–2 record and a 3.48 ERA. This is set to be a duel between two reliable starting pitchers and the total for this game is set at 6.5 with an expectation of both pitchers performing well.
Key Players
Michael Busch was a key contributor for the Cubs again on Wednesday. He had a three-run double that helped Chicago to win the most recent game of this series. Milwaukee’s Christian Yelich didn’t have a hit on Wednesday. But he did score twice and his ability to get on base will be key for the Brewers in this contest.
Recent team streaks
The Brewers have dropped three straight games in this series and have lost four of their last five contests. Chicago is on a three-game winning streak and the Cubs have won four of their last five contests.
Best Player Props
| Player | Prop |
|---|---|
| Christian Yelich (Brewers) | Over 1.5 Total Bases |
| Seiya Suzuki (Cubs) | Over 1.5 Total Bases |
| Quinn Priester (Brewers) | Under 5.5 Strikeouts |
Betting Trends & H2H
- Chicago has a 7-5 lead in the season series between the Cubs and Brewers.
- This is the final game of the regular-season series between these NL Central rivals.
- The Cubs have won four of their last five games against the Brewers.
- Chicago is 41-24 at home this season.
- Milwaukee is 37-28 on the road for the year.
Brewers vs Cubs Model Projection
Score Projection: Cubs 4 – Brewers 3
Win Probability: Cubs 54%, Brewers 46%
Final Thoughts
This should be a tight game thanks to a spectacular starting pitching matchup. I think the Cubs have the inside track at home and with the stability of Imanaga to lean on. I’ll back the Cubs to win this game on the moneyline as they should pull to within five games of the Brewers in the NL Central standings by the end of the day.
