Milwaukee Brewers vs Chicago Cubs Prediction – 8/20/2025
The Chicago Cubs swept a doubleheader against the Milwaukee Brewers on Tuesday. They will look to dominate the Brewers again in this contest in a game that features an excellent starting pitching matchup. Chicago is trying to chase down the Brewers in the NL Central standings and needs to keep beating them to improve their chances. Before the fourth game of this five-game series, continue reading to get our Brewers vs Cubs prediction.
Our Brewers vs Cubs Pick
- Pick: Cubs moneyline
- Confidence: 4/5
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Game Snapshot
- Matchup: Milwaukee Brewers vs Chicago Cubs
- Date & Time: Wednesday, August 20, 2025, at 8:05 p.m. ET
- Starting Pitchers:
- Milwaukee — Jacob Misiorowski (4-1, 3.89 ERA)
- Chicago — Colin Rea (9-5, 3.99 ERA)
- Stadium: Wrigley Field, Chicago, IL
- Broadcast: MARQ and FDSWI
Key Storylines
Pitching matchup
Jacob Misiorowski enters the game with a solid 4-1 record and a 3.89 ERA. Misiorowski is winless in his three outings since the All-Star break. He gave up five earned runs in his last start and will try to bounce back here. Colin Rea brings a 9-5 record and 3.99 ERA to the mound for Chicago. This is an evenly matched starting pitching matchup for the most part and it could end up deciding this game.
Key Players
Andrew Vaughn drove in the only run for the Brewers in the second game of their doubleheader loss last night. He is hitting .323 since joining the Brewers from the Chicago White Sox and will be key for Milwaukee tonight. Chicago will rely on weapons like Michael Busch. Busch had multi-RBI game in the second game of yesterday’s doubleheader and he will try to help Chicago win a third straight tonight.
Recent team streaks
The Brewers lost two straight games yesterday but they have been one of the hottest teams in baseball since the break. The Cubs have won four of their last five games. They swept yesterday’s twin bill against the Brewers and are seven games back of the Brewers in the NL Central standings.
Best Player Props
| Player | Prop |
|---|---|
| Christian Yelich (MIL) | Over 1.5 Total Bases |
| Jacob Misiorowski (MIL) | Under 5.5 Strikeouts |
| Michael Busch (CHC) | Over 1.5 Total Bases |
Betting Trends & H2H
- The Cubs took a 6-5 lead in the season series with the Brewers after their sweep on Tuesday.
- The Brewers are 44-25 in night games this year.
- Chicago is 38-29 at night in 2025.
Brewers vs Cubs Model Projection
Score Projection: Cubs 5 – Brewers 3
Win Probability: Chicago 56%, Milwaukee 44%
Final Thoughts
Jacob Misiorowski was great in the first half of this season but he has struggled since the All-Star break. We should see the Cubs take advantage of his recent woes. I’ll take the Cubs to win this game at home and for them to move within six games of the Brewers in the NL Central standings.
