Miami Marlins vs Cleveland Guardians Prediction – 8/13/2025

The Cleveland Guardians got some late-game heroics to beat the Miami Marlins in Tuesday’s series opener from Progressive Field. They will look for a second straight win over the Marlins on Wednesday night. But the Marlins won’t go quietly with young ace Eury Perez on the mound in this matchup. Here, I break this game down from a betting perspective and give you my Marlins vs Guardians prediction.

Our Marlins vs Guardians Pick

  • Pick: Miami Marlins Moneyline
  • Confidence: 3/5
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Game Snapshot

  • Matchup: Miami Marlins vs Cleveland Guardians
  • Date & Time: Wednesday, August 13, 2025, 6:40 PM ET
  • Starting Pitchers: Eury Pérez (MIA) vs Gavin Williams (CLE)
  • Stadium: Progressive Field, Cleveland, OH
  • Broadcast: CLEG and FDSFL

Key Storylines

  • Pitching matchup: Eury Pérez has been outstanding over the last six weeks. He has only allowed four earned runs over 34 innings. Gavin Williams recently carried a no-hit bid into the ninth inning in his last outing. Both pitchers are volatile but clearly have high ceilings.
  • Key players: The player to watch in this game is Jose Ramirez of the Guardians. Ramirez hit two home runs for Cleveland on Tuesday. The second of those home runs was the game-winner in the bottom of the eighth inning. Ramirez became the club’s all-time leader in multi-home run games and it will be interesting to see how he performs here after that game.
  • Recent team streaks: The Guardians have won four out of five games and are six games back of the first-place Detroit Tigers in the AL Central. Miami has lost four straight games and are now five games below .500.

Best Player Props

PlayerProp
Kyle Stowers (MIA)Over 0.5 Home Runs
Jose Ramírez (CLE)Over 1.5 Total Bases
Eury Pérez (MIA)Over 5.5 Strikeouts
  • The first game between these teams went under the total.
  • Miami is 29-24 in night games this season.
  • Cleveland is 25-23 in their 2025 night games.
  • The Guardians are 26-30 after a loss this year.

Marlins vs Guardians Model Projection

Score Projection: Marlins 4 – Guardians 2

Win Probability: Miami 59%, Cleveland 41%

Final Thoughts

The Guardians showed a ton of toughness to storm back and grab the win late on Tuesday. But the Marlins should have the starting pitching edge in this game and that should help them to bounce back and even this series. I’m expecting another quality outing from Eury Perez and for Miami not to get burned by more late-game heroics.


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Home MLB Picks Miami Marlins vs Cleveland Guardians Prediction – 8/13/2025