Los Angeles Dodgers vs San Diego Padres Prediction – 8/22/2025
The Los Angeles Dodgers will face the San Diego Padres in a huge game in the NL West on Friday night. These teams enter their three-game weekend series separated by just one game and will both look for a huge win in this series opener. Before the first pitch from Petco Park, continue reading to get my Dodgers vs Padres prediction for tonight.
Our Dodgers vs Padres Pick
- Pick: Padres to win
- Confidence: 3/5
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Game Snapshot
- Matchup: Los Angeles Dodgers vs San Diego Padres
- Date & Time: Friday, August 22, 2025, 9:40 PM EDT
- Starting Pitchers: Blake Snell (LAD) vs Yu Darvish (SD)
- Stadium: Petco Park, San Diego, CA
- Broadcast: SDPA and SportsNet LA
Key Storylines
Pitching Matchup
Blake Snell has been exceptional for the Dodgers over a small sample size. He enters this start with a 3-1 record and a 1.80 ERA over 25 innings. His recent performance includes a dominant outing against the Padres on August 16. He allowed no runs in a 6-0 victory in that game. San Diego’s Yu Darvish has struggled this season. Darvish has a 2-3 record with a 5.97 ERA and 34 strikeouts over 37.2 innings. His inconsistency presents an opportunity for the Dodgers to capitalize and extend their lead in the NL West.
Key Players
- Shohei Ohtani (LAD): Ohtani is listed as day-to-day for the Dodgers and his health will be very important in this game.
- Will Smith (LAD): Smith is a consistent performer with a .303 batting average and a .502 slugging percentage for LA.
- Manny Machado (SD): Machado is leading the Padres with 21 home runs and 77 RBI. He will need to produce in this series to help his team win games.
Recent Team Streaks
- The Dodgers split a four-game series with the lowly Colorado Rockies before this series.
- The Padres enter the biggest series of their season on a three-game winning streak.
Best Player Props
| Player | Prop |
|---|---|
| Shohei Ohtani | Under 1.5 Total Bases |
| Blake Snell | Under 5.5 Strikeouts |
| Manny Machado | Over 0.5 Home Runs |
Betting Trends & H2H
- The Dodgers hold an 8-2 lead in their season series against the Padres.
- The Dodgers hold a 32-31 record away from home this season.
- San Diego is 41-21 at home for the year.
Dodgers vs Padres Model Projection
- Score Projection: Padres 5 – Dodgers 4
- Win Probability: Dodgers 50%, Padres 50%
Final Thoughts
My expectation is that this game is going to be very close throughout. The Dodgers have the starting pitching advantage with Blake Snell. But San Diego is much better with their bullpen. The Padres have the beset bullpen ERA in baseball and that should help them to win this game at home even if they fall behind in the first few innings in what should be the game of the night in MLB.
