Los Angeles Angels vs Seattle Mariners Pick – 9/12/2025

The Los Angeles Angels and Seattle Mariners will face off in an AL West matchup on Friday night. September baseball in Seattle carries real stakes this year. The Mariners are in the thick of the AL West chase and are in a favorable position in the Wild Card race as well. They are favorites tonight against an Angels team with a losing record for the year. Here, I break down this Friday night contest and give you my Angels vs Mariners prediction.

Our Angels vs Mariners Pick

• Pick: Seattle Mariners -1.5
• Confidence: 4/5
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4.8/5

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Game Snapshot

• Matchup: Los Angeles Angels vs Seattle Mariners
• Date and Time: Friday, September 12, 2025, 10:10 p.m. ET
• Starting Pitchers: Yusei Kikuchi vs Luis Castillo
• Stadium: T-Mobile Park, Seattle, WA
• Broadcast: Apple TV+

Key Storylines

• The Mariners enter this game in a tie for first place in the AL West standings. They have been red-hot and the Houston Astros have struggled recently. The Mariners could end today in sole possession of first place in the division.
• Cal Raleigh’s historic power surge continues. He sits at 53 home runs and 113 RBI, pacing a power-packed Mariners lineup that has reached 200 team homers.
• The Angels’ run production has leaned on Taylor Ward and Jo Adell. Ward has driven in 97 runs, while Adell provides a long-ball threat with 35 homers.

Pitching matchup

• The Angels are set to start Yusei Kikuchi in this game. Kikuchi was an All-Star caliber pitcher in the first half of the season. But he has regressed in the second half of the year and will try to get himself back on track in this contest.
• Seattle is going with Luis Castillo on the bump here. Castillo is just 9-8 for the season but his 3.85 ERA suggests that he has been better individually than his record would suggest. This is a huge spot for the Mariners to have one of their top arms on the mound given everything that is on the line going into Friday’s play.

Recent team streaks

• The Angels had a two-game winning streak snapped with their extra-inning loss to Seattle last night.
• The Mariners have won six games in a row to move into a tie at the top of the AL West.

Best Player Props

Betting Trends & H2H

• Seattle leads the season series between these teams by a 6-4 margin.
• The Mariners are 45-27 at home on the season.
• The Angels are 32-40 on the road in 2025.

Angels vs Mariners Model Projection

Score Projection: Angels 3 – Mariners 5

Win Probability: Angels 41% – Mariners 59%

Final Thoughts

The Mariners are on fire and they have a great chance to get on top of the AL West tonight. I am going to lay the runline with the Mariners as favorites here, as they should be able to extend their winning streak to seven in a row in convincing fashion.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.