Los Angeles Angels vs Houston Astros Pick – 9/1/2025

The Los Angeles Angels and Houston Astros will close out their four-game set on Monday afternoon at Daikin Park. The Angels are looking to build on recent momentum after shutting out Houston on Sunday. The Astros will turn to a familiar face returning from a long layoff in their attempt to bounce back. Here, I have broken down this game from all angles and you can continue reading to get my Angels vs Astros prediction.

Our Angels vs Astros Pick

  • Pick: Houston Astros Moneyline
  • Confidence: ★★★★☆
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Game Snapshot

  • Matchup: Los Angeles Angels vs Houston Astros
  • Date & Time: Monday, September 1, 2025, 1:10 p.m.
  • Starting Pitchers: LHP Yusei Kikuchi (Angels) vs RHP Luis Garcia (Astros)
  • Stadium: Daikin Park, Houston, TX
  • Broadcast: Space City Home Network

Key Storylines

  • The Angels blanked the Astros 3-0 on Sunday and will look to lock up a series win today.
  • Luis Garcia makes his long-awaited return to the Astros rotation after more than two years recovering from Tommy John surgery.
  • Houston remains in the thick of the AL West race. The Angels aim to play spoiler and build toward next season.

Pitching Matchup

Yusei Kikuchi (6-9, 3.68 ERA) has been steady for Los Angeles. He has been especially strong against right-handed hitters. That could help him against Houston’s power bats. He has struggled with home runs this season. That is a concern in a hitter-friendly park today.

Luis Garcia has a career ERA of 3.69. He hasn’t pitched in MLB since May 2023. He looked sharp in Triple-A rehab appearances but this will be his first test back against a major-league lineup. Expect Houston to monitor his pitch count closely.

Recent Team Streaks

  • The Angels have won two games in a row over the Astros coming into this series finale.
  • Houston has lost two straight games and their lead in the AL West is down to two games.

Best Player Props

PlayerProp
Mike TroutOver 1.5 Total Bases
Yordan AlvarezOver 0.5 Home Runs
Yusei KikuchiOver 5.5 Strikeouts
  • The Astros hold a 5-4 lead in the season series between these teams.
  • Los Angeles has won the last two games against the Astros.
  • The under is 3-0 in the first three games of this four-game series.

Angels vs Astros Model Projection

Score Projection: Astros 5 – Angels 3

Win Probability: Astros 61%, Angels 39%

Final Thoughts

I don’t think that Luis Garcia is going to pitch much in this game. But the Astros rank in the top 10 in the league in bullpen ERA. That should help the Astros overcome a short start from Garcia here. I will take the Astros to get a win that will help them to secure a split in this series and to help them stay at least two games ahead of the Mariners in the standings after this series.


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Home MLB Picks Los Angeles Angels vs Houston Astros Pick – 9/1/2025