Kansas City Royals vs Cleveland Guardians Pick – 9/9/2025

Two playoff hopefuls will collide Tuesday as the Kansas City Royals continue a four-game set against the Cleveland Guardians. Both teams still have Wild Card hopes in the American League. Cleveland drew first blood in this series on Monday night and will try to get another huge win tonight in front of their home crowd. Before this matchup begins from Cleveland, you can find my Royals vs Guardians prediction below.

Our Royals vs Guardians Pick

• Pick: Under 8 runs
• Confidence: 3/5
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Game Snapshot

• Teams: Kansas City Royals at Cleveland Guardians
• Date and Time: Tuesday, September 9, 2025, 6:40 PM ET
• Starting Pitchers: Noah Cameron vs Joey Cantillo
• Stadium: Progressive Field, Cleveland, OH
• Broadcast: Guardians TV, FanDuel Sports Network Kansas City

Key Storylines

• Kansas City sits in the Wild Card hunt and is three games back of the Seattle Mariners for the final AL Wild Card spot.
• Cleveland is also in the chase for the Wild Card in the American League. They are within 2.5 games of the final playoff spot in the AL.
• Bobby Witt Jr. and Jonathan India are both on the injured list for the Royals. Witt is day-to-day and India is on the 10-day IL. Both could play in this game, but you will want to check on their status before placing any bets on this contest.

Pitching comparison

• Royals LHP Noah Cameron: Cameron enters this game at 7-6 with a 3.03 ERA, 1.13 WHIP, and 88 strikeouts in 113.0 innings. This young lefty has held AL lineups in check for the most part this year. His command wobbled in his last start but his advanced metrics are steady.
• Guardians LHP Joey Cantillo: Cantillo is 4-3 with a 3.73 ERA, 1.40 WHIP, and 87 strikeouts in 72.1 innings. Cantillo is coming off a quality outing at Fenway Park against the Boston Red Sox and will look to help his team in another big spot.

Recent team streaks

• The Royals have lost two games in a row and need to get back into the win column to help their playoff hopes.
• Cleveland has won four games in a row entering Tuesday’s play.

Best Player Props

Betting Trends & H2H

• Cleveland leads their season series with the Royals 6-4 entering Tuesday’s play.
• The Royals are 33-36 on the road this season.
• Cleveland is 36-33 at home after their win on Monday.

Royals vs Guardians Model Projection

Score Projection: Royals 4 – Guardians 3

Win Probability: Royals 52%, Guardians 48%

Final Thoughts

We should be in for a low-scoring game between the Royals and Guardians here. Both starting pitchers have been performing admirably and the playoff-like intensity of this game should only help the pitching staffs hang some zeroes on the scoreboard. I’ll take the under in one of the more important games of the night in baseball.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.