Kansas City Royals vs Chicago Cubs Prediction – 7/21/2025

The Kansas City Royals will travel to Wrigley Field to face the Chicago Cubs on Monday night in an interleague series opener. The Cubs find themselves in a heated race for the NL Central title despite having one of the best records in baseball this season. That makes this game a huge one for Chicago. Can the Cubbies get a much-needed win at home? Continue reading to get my Royals vs Cubs prediction for this contest.

Our Royals vs Cubs Pick

  • Pick: Chicago Cubs moneyline
  • Confidence: ★★★★☆
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Game Snapshot

  • Matchup: Kansas City Royals vs Chicago Cubs
  • Date & Time: Monday, July 21, 2025, at 8:05 p.m. ET
  • Starting Pitchers: Noah Cameron vs Ryan Brasier
  • Stadium: Wrigley Field, Chicago, IL
  • Broadcast: MLB Network, MARQ, FDSKC

Key Storylines

  • Pitching form: Noah Cameron of the Royals has delivered quality starts in four of his last five outings. Cameron is 3-4 but has a very strong 2.31 ERA. Brasier has pitched just 17.1 innings so far this season. He has a 1.04 ERA but that could increase as his sample size of innings pitched increases.
  • Bullpen usage: Both of these teams are inside the top 10 in bullpen ERA for the season. The team whose relievers execute their pitches better in this game will extract a huge advantage for their team in this contest.
  • Recent team streaks: The Royals won on Sunday but have lost three of their last five games coming into this one. The Cubs are 4-1 in their last five but lost to the Boston Red Sox on Sunday.

Best Player Props

PropPlayerPick
Home runsSalvador Perez (KC)Over 0.5
StrikeoutsNoah Cameron (KC)Over 4.5
Total basesSeiya Suzuki (CHC)Over 1.5
  • This is the first game of a three-game regular-season series between these teams.
  • Chicago is 32-17 at home on the year. Kansas City is 24-26 on the road.

Royals vs Cubs Model Projection

Score Projection: Kansas City 3 – Chicago 5

Win Probability: Kansas City 39%, Chicago 61%

Final Thoughts

The Royals deserve a ton of credit for hanging around in a crowded AL Wild Card race. But the Chicago Cubs are one of the best teams in all of baseball this season. I expect the Cubbies to win this game and do so by a couple of runs. They will continue to just hold off the Brewers in the AL Central standings for now, as they should win this game at home.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.

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