Houston Astros vs Los Angeles Dodgers Pick – 7/5/2025

The Houston Astros will go to Dodger Stadium to challenge the Los Angeles Dodgers in an interleague matchup on Saturday, July 5. The Astros won the first game of this series by an astonishing 18-1 margin. Here, the team with the best record in baseball will attempt to bounce back from that embarrassing defeat. Continue reading to get my Astros vs Dodgers prediction for Saturday night.

Our Astros vs Dodgers Pick

• Pick: Astros Moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Houston Astros @ Los Angeles Dodgers
• Date & Time: Saturday, July 5, 2025, 7:15 p.m. ET
• Starting Pitchers: Framber Valdez (9–4, 2.72 ERA) vs Shohei Ohtani (0-0, 2.75 ERA)
• Stadium: Dodger Stadium, Los Angeles, CA
• Broadcast: FOX

Key Storylines

Pitching Form

• Framber Valdez has been great this year for the Astros. He’s 9–4, with a 2.72 ERA. But he will face a tough test against the elite lineup of the Dodgers tonight.
• Shohei Ohtani has a 2.75 ERA in 4.0 innings of work. He is easing his way back into pitching after not pitching last season and a short leash tonight could make it tough for the Dodgers to win this contest.

Bullpen Usage

The Dodgers’ bullpen is a major concern of mine heading into this game. They were rocked yesterday as a part of Houston’s 18-1 win over LA on Friday. Combine that with the need to pitch for most of this game with Ohtani unlikely to go deep, and there could be a lot of strain on LA’s arms in relief once again.

Recent Team Streaks

Both teams have won 8 of their last 10 games coming into this matchup. Houston has scored five runs or more in four straight games, while the Dodgers had a similar streak snapped last night.

Best Player Props

Betting Trends & H2H

• Houston won the only game of the season series between these teams this year on Friday night.
• Houston’s 57.1% win percentage as an underdog this season is the best in MLB.

Houston Astros vs Los Angeles Dodgers Model Projection

Score Projection: Dodgers 6 – Astros 5

Win Probability: Dodgers 53%, Astros 47%

Final Thoughts

If Shohei Ohtani was able to pitch a normal length of time, the Dodgers would likely win this game. But with Ohtani’s outings still being short as he returns to the mound, I expect the Astros to come away with the win here. Valdez has been very consistent for Houston and that should remain the case in this game, even against one of the best offenses in baseball.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.