The Houston Astros will face the Los Angeles Angels on Friday night at Angel Stadium in Anaheim. The Astros are a game out of the final American League Wild Card spot with just days left in the regular season. They need to win the majority of their games in this series to have a chance to make it into postseason play. Before the first game of this huge series begins, continue reading to get my Astros vs Angels prediction for Friday night.
Our Astros vs Angels Pick
- Pick: Astros Moneyline
- Confidence: 3/5
Game Snapshot
- Matchup: Houston Astros vs Los Angeles Angels
- Date & Time: Friday, September 26, 2025, 9:38 PM ET
- Starting Pitchers: Jason Alexander (HOU) vs Kyle Hendricks (LAA)
- Stadium: Angel Stadium, Anaheim, CA
- Broadcast: FDSW / SCHN
Key Storylines
- Houston is in a do-or-die mode in their final games. They are still alive for a Wild Card spot but need to take advantage of this opportunity against a lower-tier opponent.
- The Angels have struggled offensively and are well below average in batting average. They possess decent power metrics and will need to figure out a way to hit for power to steal this game from Houston.
Pitching matchup
On the mound for Houston is Jason Alexander. He enters with a 4-2 record and a 4.83 ERA and a 1.39 WHIP. He’s had mixed results recently and is not necessarily who the Astros want on the hill in a spot this important. Kyle Hendricks will get the start for the Angels in this contest. He carries an 8-10 record with a 4.79 ERA and a 1.28 WHIP. The Astros have had success against Angels starters and will try to continue to do so against Hendricks here.
Recent team streaks
Houston has seen turbulence lately. They snapped a five-game losing streak with an 11-5 win over Oakland on Thursday. Prior to that, they had multiple games where their offense stalled. The Angels have lost eight of their last 10 games and have settled at the bottom of the AL West standings for the season.
Best Player Props
| Player | Prop |
|---|---|
| Jose Altuve | Over 0.5 Home Runs |
| Carlos Correa | Over 1.5 Total Bases |
| Jason Alexander | Over 4.5 Strikeouts |
Betting Trends & H2H
- Houston holds a 6-4 lead in their season series against the Angels. The Astros can clinch this season series with a win in any of the three games they play this weekend.
- Houston is a .500 team on the road at 39-39.
- The Angels are 38-40 at home on the year.
Astros vs Angels Model Projection
Score Projection: Astros 5 – Angels 3
Win Probability: Astros 58%, Angels 42%
Final Thoughts
Houston enters this game with a sense of urgency, a more balanced lineup, and a slight edge in the pitching matchup. I think that we will see the Astros get a win in this game to keep pressure on the Red Sox and Tigers. With Boston and Detroit playing against each other, someone has to lose that game, and the Astros should take advantage by winning this series opener on the road.
