Houston Astros vs Baltimore Orioles Pick – 8/22/2025
The Houston Astros got a convincing win in their series opener against the Baltimore Orioles on Thursday. These American League teams will face off again on Friday in the second game of their four-game series. This game is basically a pick ’em and both teams will feel like they have a shot to get the victory in this matchup. Before the fun begins in Baltimore, continue reading to get my Astros vs Orioles prediction for the day.
Our Astros vs Orioles Pick
- Pick: Baltimore Orioles moneyline
- Confidence: ★★★☆☆
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Game Snapshot
- Matchup: Houston Astros vs Baltimore Orioles
- Date & Time: Friday, August 22, 2025, 7:05 p.m. ET
- Starting Pitchers: Lance McCullers Jr. (HOU) vs Cade Povich (BAL)
- Stadium: Oriole Park at Camden Yards, Baltimore, MD
- Broadcast: MLB Network, MASN, SCHN
Key Storylines
Pitching matchup
Lance McCullers Jr. returns to action with a 2-4 record and an elevated 6.90 ERA. He’s only logged 44.1 innings this season and will look to establish a rhythm in this contest. Cade Povich is 2-6 with a 4.98 ERA and 1.44 WHIP over 81.1 innings for the Orioles. Povich has had a worse ERA at home than on the road and the Orioles will hope that doesn’t burn them in this game.
Key Players
- Astros: Christian Walker and Yainer Diaz both hit two-run home runs for the Astros last night and they will look to make a similar impact tonight.
- Orioles: Dylan Beavers drove in the only two runs for Baltimore on Thursday and Baltimore could use more production from the bottom of their order in this contest.
Recent team streaks
Houston snapped an extended losing streak by winning Thursday night’s game. Baltimore had a three-game winning streak snapped by the Astros last night and Baltimore will aim to get back into the win column here.
Best Player Props
| Player | Prop |
|---|---|
| Jose Altuve | Under 1.5 Total Bases |
| Gunnar Henderson | Over 0.5 Home Runs |
| Cade Povich | Over 4.5 Strikeouts |
Betting Trends & H2H
- The season series between these teams is tied 2-2.
- The road team has won three of the first four games between these teams in 2025.
- Three of the four games between the Orioles and Astros have seen nine or fewer runs scored this season.
Astros vs Orioles Model Projection
Score Projection: Orioles 5 – Astros 4
Win Probability: Orioles 55%, Astros 45%
Final Thoughts
The Orioles have been playing well lately in spite of their slip-up against the Astros on Thursday. I expect Houston to struggle to keep Baltimore off the scoreboard in this game thanks to the struggles of McCullers for the year. I’ll take the Orioles to win this game at home as they should make it four wins in their last five contests.
