Houston Astros vs Arizona Diamondbacks Prediction – 7/22/2025
The Houston Astros enter Tuesday’s matchup against the Arizona Diamondbacks with a clear edge on the mound and in recent form. The Astros are favored with Framber Valdez on the mound. Can the Astros continue their winning ways, or will Arizona get back to the .500 mark with a win at home? Find out what I think below as I make my Astros vs Diamondbacks prediction for Tuesday night. Pitching is going to be the key factor that separates the Astros and Diamondbacks on Tuesday night. The Astros have the better starting pitcher going in this game with Valdez on the mound. And even if Valdez struggles, the Astros have a much better bullpen to help them catch up late. I expect Houston to win this game convincingly thanks to its pitching advantages. I will lay the runline with the Astros in this spot.Our Astros vs Diamondbacks Pick
Game Snapshot
Key Storylines
Best Player Props
Player Prop Framber Valdez Over 6.5 Strikeouts Brice Matthews 1+ Home Run Eugenio Suárez Over 1.5 Total Bases Betting Trends & H2H
Astros vs Diamondbacks Model Projection
Final Thoughts
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ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
