Houston Astros vs Arizona Diamondbacks Prediction – 7/22/2025

The Houston Astros enter Tuesday’s matchup against the Arizona Diamondbacks with a clear edge on the mound and in recent form. The Astros are favored with Framber Valdez on the mound. Can the Astros continue their winning ways, or will Arizona get back to the .500 mark with a win at home? Find out what I think below as I make my Astros vs Diamondbacks prediction for Tuesday night.

Our Astros vs Diamondbacks Pick

• Pick: Astros -1.5
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Houston Astros vs Arizona Diamondbacks
• Date & Time: Tuesday, July 22, 2025, 9:40 PM ET
• Starting Pitchers: Framber Valdez (HOU) vs Eduardo Rodríguez (ARI)
• Stadium: Chase Field, Phoenix, AZ
• Broadcast: ARID and SCHN

Key Storylines

• Pitching Form: Framber Valdez has been exceptional for the Astros. He has a 10-4 record with a 2.75 ERA and 1.12 WHIP this season. The Astros have had a ton of success in the games he has started and will look to continue that trend tonight. Arizona’s Eduardo Rodríguez has struggled. He has a 3-6 record with a 5.94 ERA and 1.67 WHIP this season.
• Bullpen Usage: The bullpen mismatch in this series is a huge factor that I urge bettors not to overlook. Houston ranks third in the league in bullpen ERA this year. Arizona is 26th in that department in 2025. That helped Houston win on Monday night and could play a role again on Tuesday.
• Recent Team Streaks: The Astros have won two straight games going into this contest. The Diamondbacks had a four-game winning streak snapped with their loss on Monday to the Astros.

Best Player Props

Betting Trends & H2H

• The Astros lead the season series 1-0 over the Diamondbacks after winning on Monday. They can clinch the season series with a win tonight.
• Both teams are below .500 on the runline this season.
• The first game between these teams went over the total of 8.5 runs. There were nine runs scored in that game.

Astros vs Diamondbacks Model Projection

• Score Projection: Astros 6 – Diamondbacks 3
• Win Probability: Astros 59.4%, Diamondbacks 40.6%

Final Thoughts

Pitching is going to be the key factor that separates the Astros and Diamondbacks on Tuesday night. The Astros have the better starting pitcher going in this game with Valdez on the mound. And even if Valdez struggles, the Astros have a much better bullpen to help them catch up late. I expect Houston to win this game convincingly thanks to its pitching advantages. I will lay the runline with the Astros in this spot.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.