Houston Astros vs Arizona Diamondbacks Prediction – 7/21/2025
The Houston Astros continue their road trip at Chase Field on Monday night with a game against the Arizona Diamondbacks. Houston arrives having struggled in recent games against division opponents. Arizona has been playing well and will look to keep doing so to help their Wild Card chances. Here, I break this game down from all angles and give you my Astros vs Diamondbacks prediction. Score Projection: Houston 4 – Arizona 5 Win Probability: Houston 45%, Arizona 55% The Astros have a statistical edge with both their starting pitching and their bullpen going into this game. But Zac Gallen has a higher ceiling than any of the pitchers that we expect to see significant action in this game. I expect Gallen to pitch well and for the Astros to win the first game of this interleague series from Phoenix.Our Astros vs Diamondbacks Pick
Game Snapshot
Key Storylines
Best Player Props
Player Prop Type Pick Alex Bregman Home Runs Over 0.5 Zac Gallen Strikeouts Over 6.5 José Altuve Total Bases Over 1.5 Betting Trends & H2H
Astros vs Diamondbacks Model Projection
Final Thoughts
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ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
