Houston Astros vs Arizona Diamondbacks Pick – 7/23/2025

The Houston Astros arrive in Phoenix riding a three‑game winning streak. They will look to extend that winning streak and complete a three-game sweep of the Arizona Diamondbacks on Wednesday afternoon in Phoenix. The Diamondbacks are slight favorites going into this game as they look to avoid a sweep. I have broken this game down and you can find my Astros vs Diamondbacks prediction below.

Our Astros vs Diamondbacks Pick

• Pick: Houston Astros moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Houston Astros at Arizona Diamondbacks
• Date & Time: Wednesday, July 23, 2025, 3:40 p.m. ET
• Starting Pitchers: Brandon Walter (1‑3, 3.66 ERA) vs Brandon Pfaadt (10‑6, 4.82 ERA)
• Stadium: Chase Field, Phoenix, AZ
• Broadcast: MLB Network, ARID, SCHN

Key Storylines

• Houston’s form: The Houston Astros have won three straight after shaking off a rough mid‑July stretch. They enter this game off a 3‑1 victory last night behind Framber Valdez’s stellar start and Brice Matthews’ clutch homer.
• Walter’s uptick: The lefty has delivered back‑to‑back quality starts for the Astros. He threw six innings of one-run ball in his last start against the Seattle Mariners.
• Pfaadt’s rollercoaster: The Diamondbacks’ right-hander has posted three straight starts of at least five innings but carries a higher ERA and WHIP than Walter. He struggled earlier in the year but is starting to round into form.
• Bullpen battle: Arizona’s bullpen has the fifth-highest bullpen ERA in MLB this season. That could be a concern for the Diamondbacks again tonight.
• Arizona’s offense: Despite last night’s loss, the Diamondbacks remain potent at the plate. Eugenio Suárez has 36 homers and 86 RBI. Josh Naylor has solid triple‑slash numbers. The team ranks among the MLB’s top five in slugging.

Best Player Props

Betting Trends & H2H

• The Astros lead the season series between these teams 2-0.
• Today’s game is the final regular season game scheduled between these teams in 2025.
• Arizona enters this game at 26-27 at home after dropping the first two games of this series.

Astros vs Diamondbacks Model Projection

Score Projection: Astros 5 – Diamondbacks 3

Win Probability: Astros 55%, Diamondbacks 45%

Final Thoughts

Brandon Pfaadt has been better than some of his numbers would indicate this season. But he still has a lot to sort out against a dangerous Astros lineup. Expect Houston to get off to a strong start offensively and for their bullpen superiority to once again make the difference late. Houston should win this game and secure a sweep of the snakes on Wednesday afternoon.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.