Detroit Tigers vs Pittsburgh Pirates Prediction – 7/22/2025

The Detroit Tigers were beaten by Paul Skenes and the Pittsburgh Pirates in the opening game of their three-game series on Monday night. The Tigers will look to bounce back from that loss on Tuesday without Skenes on the bump. Here, I have broken this interleague game down from all angles. You can continue reading to get my Tigers vs Pirates prediction for Tuesday night.

Our Tigers vs Pirates Pick

• Pick: Detroit Tigers moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Detroit Tigers vs Pittsburgh Pirates
• Date & Time: Tuesday, July 22, 2025, 6:40 PM ET
• Starting Pitchers: Casey Mize vs Mitch Keller
• Stadium: PNC Park, Pittsburgh, PA
• Broadcast: SportsNet PT and FDSDET

Key Storylines

• Pitching form: Casey Mize has been stellar with a 9‑3 record and 3.15 ERA. He earned an All‑Star nod this year and will look to continue to pitch well in the second half of the season. Pittsburgh’s Mitch Keller is solid with a 3.48 ERA but he has a 3‑10 record thanks to a lack of run support from the Pirates.
• Bullpen usage: Neither team should be in bad shape with their bullpen in this contest. Things were manageable on both sides in yesterday’s 3-0 win for the Pirates.
• Recent team streaks:
  • The Tigers have lost four of their last five games coming into this contest. That includes their loss in Monday’s series opener.
  • Pittsburgh snapped a three-game losing streak with their win last night.

Best Player Props

Betting Trends & H2H

• The season series between these teams is tied 2-2.
• Three of the four games between these teams have seen 10 or more runs scored by the two teams.
• Detroit has gone over the total in 52% of their games this season.
• Pittsburgh has stayed under the total in 58.2% of their games.

Tigers vs Pirates Model Projection

Score Projection: Detroit Tigers 5 – Pittsburgh Pirates 3

Win Probability: Tigers 57%, Pirates 43%

Final Thoughts

This is a prime spot for the Tigers to bounce back after their loss to Skenes and the Pirates on Monday night. Skenes is no longer someone the Tigers have to contend with during this series. Now the Tigers will have the starting pitching advantage with Mize on the bump. Look for Mize to help the Tigers to get a win here that will move Detroit back to 20 games above .500 for the year.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.