Colorado Rockies vs San Diego Padres Pick – 9/12/2025

The Colorado Rockies will visit the San Diego Padres on Friday night at Petco Park. The Padres are chasing postseason positioning and they have a golden opportunity to gain ground against the worst team in baseball this weekend. San Diego is a heavy favorite going into this game and you can find out if I think if that is justified with my Rockies vs Padres prediction below.

Our Rockies vs Padres Pick

  • Pick: Padres -1.5
  • Confidence: 3/5
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Game Snapshot

  • Teams: Colorado Rockies vs San Diego Padres
  • Date & Time: Friday, September 12, 2025, 9:40 PM ET
  • Starting Pitchers: Tanner Gordon vs JP Sears
  • Stadium: Petco Park, San Diego, CA
  • Broadcast: Padres.TV in San Diego, Rockies.TV in Colorado

Key Storylines

  • The Padres are 2.5 games back of the LA Dodgers in the NL West standings going into this weekend’s play. San Diego is also holding onto the second Wild Card spot in the National League and they have a chance to improve their prospects in both of those races here.
  • The Padres have dominated the season series against the Rockies going into this game. But they cannot afford to take this game for granted. Just because the Rockies have struggled all year, that doesn’t mean that they are going to struggle here. San Diego will need to remain locked in to avoid a devastating upset loss.

Pitching Outlook

Tanner Gordon gets the start for the Rockies in this game. Gordon is 5-6 and has a 6.60 ERA for the year. He could be in danger against the potent offense of the Padres in this contest. Gordon will be opposed by San Diego’s JP Sears. Sears hasn’t been great this year by any means. He is 8-10 and has a 5.01 ERA this year. Sears has gone from playing for the Athletics earlier in the season to being in a playoff race with the Padres. He will try to take advantage of that massive opportunity in games like this one.

Recent Team Streaks

  • The Rockies have lost six games in a row going into this contest.
  • The Padres have lost two of their last three games but they won the opening game of this series last night.

Best Player Props

CategoryPlayerPick
Home RunManny MachadoYes
StrikeoutsJP SearsOver 4.5
Total BasesManny MachadoOver 1.5
Total BasesHunter GoodmanOver 1.5
  • The Padres are 8-2 against the Rockies so far this season.
  • The Padres have won three straight games against Colorado.

Rockies vs Padres Model Projection

Score Projection: Rockies 2 – Padres 5

Win Probability: Rockies 32%, Padres 68%

Final Thoughts

The Padres have a massive advantage over the Rockies going into this contest. As long as the Padres aren’t impacted by the pressure of their playoff race, they should be able to win this game convincingly at home. I’ll lay the runline with the Padres here as they should get a second straight win over Colorado tonight.


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Home MLB Picks Colorado Rockies vs San Diego Padres Pick – 9/12/2025