Colorado Rockies vs Cleveland Guardians Prediction – 7/28/2025

The Colorado Rockies and Cleveland Guardians will open a three-game interleague series on Monday night. The Guardians have had a much better season than the Rockies and will look to beat their struggling visitors at home. But nothing is ever guaranteed in baseball. Here, I take a closer look at this game and bring you my Rockies vs Guardians prediction.

Our Rockies vs Guardians Pick

  • Pick: Guardians -1.5
  • Confidence: ★★★★☆
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Game Snapshot

  • Matchup: Colorado Rockies at Cleveland Guardians
  • Date & Time: Monday, July 28, 2025, 6:40 PM ET
  • Starting Pitchers: Bradley Blalock (1–2, 8.67 ERA) vs Slade Cecconi (5–4, 3.76 ERA)
  • Stadium: Progressive Field, Cleveland, OH
  • Broadcast: MLB.tv

Key Storylines

Pitching matchup

Bradley Blalock has struggled in his limited action this season for the Rockies. He is 1-2 with an 8.67 ERA in 27 innings of work. He has given up 41 hits in 27 innings and will need to stop getting lit up to see his ERA come down. Slade Cecconi has been steady on the hill for the Guardians this year. He has a 3.76 ERA and has gone 5-4 so far this year. He offers the Guardians a reliable arm for a night game at home and he will look to take advantage of a start against baseball’s worst team.

Key Players

  • Colorado – Hunter Goodman: Goodman is the Rockies’ team leader in home runs, RBI, and batting average. He remains one of the few bright spots in a dismal Colorado lineup.
  • Cleveland – José Ramírez: Jose Ramirez also leads his team in home runs, RBI, and batting average. He is a slightly better power hitter than Goodman and that could make a key difference in this contest.

Recent team streaks

  • The Rockies have lost two straight games to the Baltimore Orioles going into this game.
  • Cleveland lost three of its last four games. They most recently dropped two out of three to the Kansas City Royals.

Best Player Props

PlayerProp Type
Hunter Goodman (COL)1+ Home Runs
Slade Cecconi (CLE)Over 5.5 Strikeouts
José Ramírez (CLE)Over 1.5 Total Bases
  • This is the first game of a three-game season series between the Rockies and Guardians.
  • Cleveland is 25-25 at home this year.
  • Colorado is 13-40 on the road in 2025.
  • Colorado is 43-62 on the runline this year. That is the worst record in MLB against the runline.
  • Cleveland is 55-50 on the runline in 2025.

Rockies vs Guardians Model Projection

Score Projection: Rockies 3 – Guardians 5

Win Probability: Rockies 39%, Guardians 61%

Final Thoughts

The Guardians have been mediocre at home throughout this season. But mediocre should be more than good enough to beat the Rockies with some margin. Cecconi has been impressive on the bump for the Guardians this year. I expect that to continue and for the Guardians to win and cover the runline as a favorite on Monday.


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Home MLB Picks Colorado Rockies vs Cleveland Guardians Prediction – 7/28/2025