The Cleveland Guardians and Minnesota Twins will face off in AL Central competition on Sunday afternoon in Minneapolis. The Guardians are riding an impressive wave of momentum into this series finale. That has put the Guardians back in contention to win the AL Central, something that looked impossible just a few weeks ago. Before the action begins from Minneapolis, continue reading to get my Guardians vs Twins prediction.
Our Guardians vs Twins Pick
- Pick: Guardians Moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Cleveland Guardians vs Minnesota Twins
- Date & Time: Sunday, September 21, 2025, 2:10 p.m. ET
- Starting Pitchers: Joey Cantillo (Guardians) vs Simeon Woods Richardson (Twins)
- Stadium: Target Field, Minneapolis, MN
- Broadcast: MNNT and CLEG
Key Storylines
Pitching matchup
Joey Cantillo has been solid this season with a 3.27 ERA. His recent results have been positive and his team tends to perform well when he starts, including covering the runline on a consistent basis. Simeon Woods Richardson has a higher ERA but will try to take advantage of pitching at home in this contest. The edge goes to Cantillo in terms of consistency and control, especially in a pressure game for Cleveland.
Recent team streaks
- Cleveland has won its last 10 games, including a doubleheader sweep of Minnesota on Saturday.
- The Guardians have shut the Twins out in back-to-back games.
- The Twins have dropped five games in a row.
Best Player Props
| Player | Prop | Pick |
|---|---|---|
| Jose Ramírez (CLE) | Home Runs | Over 0.5 |
| Byron Buxton (MIN) | Total Bases | Over 1.5 |
Betting Trends & H2H
- The Guardians hold a 9-3 advantage in their season series against the Twins.
- This is the final game of the season scheduled between the Twins and Guardians.
- Cleveland enters this game tied for the final AL Wild Card spot and one game back of the Tigers in the AL Central standings.
Guardians vs Twins Model Projection
Score Projection: Cleveland Guardians 5 – Minnesota Twins 3
Win Probability: Cleveland 60%, Minnesota 40%
Final Thoughts
Cleveland enters this game with a head of steam. Their pitching, bullpen, and recent performance have all been excellent. Joey Cantillo gives them a chance to stifle Minnesota’s lineup, while the Twins have too many pitching and offensive inconsistencies to feel confident. Given Cleveland’s sense of urgency, the trends, and the betting lines, backing the Guardians straight up offers value in what should be a competitive series finale from Target Field.
