The Cleveland Guardians will take on the Minnesota Twins in an AL Central matchup on Friday night. The Guardians enter Friday’s matchup on a seven-game winning streak that has revitalized their postseason aspirations. Here, they will look for an eighth straight win and a second straight over Minnesota in this series. Continue reading below to get my thoughts on this game, including my Guardians vs Twins prediction.
Our Guardians vs Twins Pick
- Pick: Guardians to win
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Cleveland Guardians vs Minnesota Twins
- Date & Time: Friday, September 19, 2025, 8:10 PM ET
- Starting Pitchers: Parker Messick (CLE) vs Pablo López (MIN)
- Stadium: Target Field, Minneapolis, MN
- Broadcast: MNNT (Twins), CLEG (Guardians)
Key Storylines
Pitching Matchup
Parker Messick is off to a nice start for the Cleveland Guardians. He is 3-0 with a 1.84 ERA on the season. He is giving up over a hit per inning in his 29.1 innings of work late in the year. But he has only allowed one home run and limiting that kind of dangerous contact will be huge for Messick again in this game.
Pablo López will get the start for the Twins here. Lopez has a 5-4 record with a 2.64 ERA. While his numbers are solid, he faces a Guardians lineup that has been in excellent form recently. Lopez has allowed under a hit per inning on the year and will need to keep the bases clear to avoid major damage if the Guardians can find some power.
Recent Team Streaks
- Guardians: The Guardians are winners of seven consecutive games. That winning streak includes a sweep over the Tigers, showcasing just what the Guardians are capable of at this point in the season.
- Twins: Minnesota has dropped two games in a row and four of their last five. The Twins will aim to disrupt the Guardians’ momentum and play the role of spoilers here.
Best Player Props
| Player | Prop |
|---|---|
| José Ramírez | Over 0.5 Home Runs |
| Byron Buxton | Over 0.5 Home Runs |
Betting Trends & H2H
- The Guardians hold a 6-3 lead in their season series with the Twins.
- Cleveland is 40-37 on the road this season.
- Minnesota is 37-40 at home during the 2025 campaign.
- Cleveland is 31-14 against AL Central opponents this year.
- Minnesota is 19-29 against division opponents for the season.
Guardians vs Twins Model Projection
- Score Projection: Guardians 5 – Twins 3
- Win Probability: Guardians 60%, Twins 40%
Final Thoughts
Given the Guardians’ current form, they are well-positioned to extend their winning streak in Minnesota. While the Twins have a very good starting pitcher on the mound in Lopez, the Guardians’ momentum and recent performances suggest they will secure a victory in this matchup. I recommend taking the Guardians to win this game on the moneyline, as Messick should have another strong performance on the bump for Cleveland.
