Cleveland Guardians vs Minnesota Twins Pick – 5/21/2025

As the Minnesota Twins get set to host the Cleveland Guardians on May 21, 2025, both teams are facing an interesting set of circumstances. They will complete a game that was suspended in the fourth inning on Monday before playing a second game later in the day. They were supposed to complete the suspended game and play again on Tuesday, but rain washed that out as well, leading us to get more than a game and a half of action on Wednesday instead.

Currently, the Twins sit at 26-21, holding a slight edge over the Guardians, who are at 25-21. The Twins are one of the hottest teams in baseball right now, having won 14 of their last 15 games. They will send Chris Paddack to the mound for the full game on the schedule today. Paddack is 2-3 on the year witha 4.05 ERA.

For Cleveland, it will be Gavin Williams on the bump when the second game of the day between these teams takes place. Williams is similar to Paddack statistically, going 3-2 on the year with a 4.29 ERA. Williams hasn't pitched more than five innings in a game in a month and some longevity out of him would be huge here given the bullpen implications of playing close to two full games in one day.

Batting-wise, both teams have had their struggles this season. The Twins rank 20th in MLB in overall offense, while the Guardians sit slightly lower at 22nd. This could put pressure on both lineups to capitalize on scoring opportunities, especially with two solid pitchers on the mound.

With the Twins' potent bullpen ranked 3rd in MLB and the Guardians' at 11th, the late innings could be crucial in determining the outcome. With a close moneyline set at -120 for the Twins and +100 for the Guardians, betting markets are anticipating a tightly contested match.

Cleveland Guardians vs Minnesota Twins Prediction

Predicted Final Score: Cleveland Guardians 3.73, Minnesota Twins 3.63

• Date: May 21, 2025
• Venue: Target Field
• Starting Pitchers:
  • Gavin Williams - Guardians
  • Chris Paddack - Twins

Get daily MLB picks here.