The Cleveland Guardians will face the Minnesota Twins in the second game of their doubleheader on Saturday evening. The Guardians are one of the hottest teams in baseball right now and they will try to overcome the volatility of a doubleheader to try and continue their winning ways. Before this matchup starts from Minneapolis, you can keep reading to get my Guardians vs Twins Game 2 prediction.
Our Guardians vs Twins Game 2 Pick
- Pick: Guardians to win
- Confidence: 3/5
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Game Snapshot
- Matchup: Cleveland Guardians vs Minnesota Twins
- Date & Time: Saturday, September 20, 2025, 2:10 PM EDT
- Starting Pitchers: Slade Cecconi (Guardians) vs Bailey Ober (Twins)
- Stadium: Target Field, Minneapolis, MN
- Broadcast: MLB.tv
Key Storylines
- Pitching matchup: Slade Cecconi (6-6, 4.39 ERA) takes the mound for Cleveland, while Minnesota counters with Bailey Ober (5-8, 5.12 ERA). Cecconi has shown promise in recent outings, and the Guardians’ bullpen has been effective, ranking 4th in bullpen ERA. Ober has struggled with consistent command, which could be advantageous for Cleveland’s offense.
- Key Players: José Ramírez continues to be a standout for the Guardians. He leads the team in home runs, RBI, and batting average. Byron Buxton remains a key offensive threat for the Twins. He is also leading his team in the big three offensive stat categories.
- Recent team streaks: The Guardians have won eight consecutive games and that has helped them hang around in the Wild Card race. The Twins have faced challenges with three straight losses going into the day’s doubleheader action.
Best Player Props
| Player | Prop |
|---|---|
| José Ramírez | Over 0.5 home runs |
| Slade Cecconi | Over 4.5 Strikeouts |
| Bailey Ober | Under 5.5 strikeouts |
Betting Trends & H2H
- The Guardians have won eight straight games entering Saturday.
- The Twins have lost seven of their last eight games.
- Cleveland has won four of the last five games between these teams coming into the doubleheader on Saturday.
Guardians vs Twins Game 2 Model Projection
- Score Projection: Guardians 5 – Twins 3
- Win Probability: Guardians 56%, Twins 44%
Final Thoughts
The Guardians are playing better baseball across the board going into this matchup. The doubleheader can cause some chaos for these teams, as they will need to navigate resting players and managing their bullpens heading into Game 2. We should see the Guardians handle those strange situations the most effectively. I’ll take Cleveland to win the second game of this twin bill and for the Guardians to continue to put pressure on the teams ahead of them in the AL Wild Card race.
