The Cleveland Guardians and Minnesota Twins will begin a doubleheader on Saturday afternoon in Minneapolis. Cleveland enters Game 1 of Saturday’s doubleheader with momentum on their side, having secured an eighth consecutive victory over Minnesota in Friday’s series opener. Cleveland will look for another key win in this game and you can find my Guardians vs Twins Game 1 prediction below.
Our Guardians vs Twins Game 1 Pick
- Pick: Guardians to win Game 1
- Confidence: 3/5
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Game Snapshot
- Matchup: Cleveland Guardians vs Minnesota Twins
- Date & Time: Saturday, September 20, 2025, 2:10 PM EDT
- Pitching Matchup: Logan Allen vs Joe Ryan
- Stadium: Target Field, Minneapolis, MN
- Broadcast: MLB.tv
Key Storylines
Pitching Matchup
Guardians left-hander Logan Allen (7-11, 4.36 ERA) takes the mound for Cleveland. Allen is giving up around a hit per inning this season and his walk numbers have pushed his WHIP to a high 1.43 this year. He’ll face Twins ace Joe Ryan (13-8, 3.35 ERA), who has been a consistent performer. He leads Minnesota’s pitching staff with 180 strikeouts over 161 innings.
Recent Team Streaks
- Guardians: Cleveland is on an eight-game winning streak. They have a balanced offense that can hit for power or manufacture runs. They also have a bullpen that ranks fourth in ERA at 3.50.
- Twins: Minnesota has struggled recently, dropping five of their last six games. Their pitching staff ranks 24th in starting ERA and 26th in bullpen ERA.
Best Player Props
| Player | Prop |
|---|---|
| Joe Ryan | Over 5.5 Strikeouts |
| José Ramírez | Over 0.5 Home Runs |
Betting Trends & H2H
- The Guardians hold a 7-3 lead in the season series against Minnesota.
- Cleveland has already clinched this year’s season series with the Twins with three games left between these teams.
- This is Cleveland’s fifth doubleheader this season. They have split the previous four.
- This is Minnesota’s second doubleheader of the year. Minnesota split its first doubelheader against the Baltimore Orioles.
Guardians vs Twins Game 1 Model Projection
- Score Projection: Guardians 5 – Twins 3
- Win Probability: Guardians 60%, Twins 40%
Final Thoughts
Cleveland is playing some excellent baseball at the right time to do so. The Guardians have fought to within 1.5 games of the final Wild Card spot in the American League and they could find themselves playing in October again if they can keep winning games the way they have. I’ll take the Guardians to win this game on the road to start this doubleheader and to extend the Cleveland winning streak to eight games in a row.
