Cleveland Guardians vs Houston Astros Pick – 7/9/2025
The Cleveland Guardians and Houston Astros will play the final game of their three-game series on Wednesday. Cleveland came into this series on a long losing streak but have managed to steal the first two games on the road. They will look for a series sweep of the Astros in this game, while the Astros look to salvage a game. Here, I break down this American League matchup and make my Guardians vs Astros prediction.
Our Guardians vs Astros Pick
Pick: Astros moneyline
Confidence: ★★★★☆
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Pitching form: Slade Cecconi has a 3-4 record and a 3.56 ERA. Brandon Walter is 1–1 with a 4.15 ERA in six appearances. Neither of these pitchers have been bad but they haven’t been anything special either.
Bullpen usage: The Astros still have a top-three bullpen in MLB in terms of bullpen ERA. But they have struggled in this series against the Guardians so far. If that changes, Houston could get on the board in this three-game set.
Recent team streaks: The Astros are losers of two games in a row to the Guardians. Cleveland is still just 2-8 in their last 10 games after winning their last two.
Best Player Props
Prop
Odds
Jose Altuve Over 0.5 HR
+400
Jose Ramírez Over 0.5 HR
+350
Yainer Díaz Over 1.5 Hits
+195
Betting Trends & H2H
Last 5 games: Astros 3-2, Guardians 2–3
Day/Night splits: The Guardians are 24-30 in night games this year. The Astros are 34-27 in night games.
Runline Records: The Guardians are 47-43 on the runline this year. Houston is 44-48 in their games.
This series has been one where the Guardians have been winning in spite of the statistical advantages of the Astros. I don’t expect that to continue here. The Astros should get one game out of this series, as their bullpen should find a way to turn things around against the Guardians’ lineup. Expect Houston to win this game and for the runline to be worth considering with them on top of the moneyline.
Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.
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Affiliate Disclosure ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.
Home›MLB Picks›Cleveland Guardians vs Houston Astros Pick – 7/9/2025
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