Cleveland Guardians vs Chicago White Sox Prediction – 7/12/2025

Saturday’s AL Central showdown at Rate Field features the Cleveland Guardians heading into Chicago to take on the White Sox. These teams split a doubleheader yesterday and will be looking to gain a clear advantage in this four-game series before they close out the first halves of their respective seasons Sunday. Continue reading to get my analysis of this division matchup, which includes my Guardians vs White Sox prediction.

Our Guardians vs White Sox Pick

• Pick: Guardians Moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Cleveland Guardians vs Chicago White Sox
• Date & Time: Saturday, July 12, 2025 at 4:10 p.m. ET
• Starting Pitchers: Tanner Bibee vs Sean Burke
• Stadium: Rate Field
• Broadcast: CHSN and CLEG

Key Storylines

• Pitching form: Tanner Bibee has battled inconsistency this season. He has a 4.35 ERA and a disappointing 4-9 record. But he is still very dangerous when he is at his best. Sean Burke has a 4-8 record and a 4.40 ERA across 92 innings. This starting pitching matchup is pretty even for the most part.
• Recent team streaks: The Guardians are 4-1 in their last five games. Their lone loss during that stretch came in the second game of Friday’s doubleheader with Chicago. The White Sox have dropped three of their last five games entering Saturday’s play.

Best Player Props

Guardians vs White Sox Model Projection

Score Projection: Cleveland Guardians 5 – Chicago White Sox 3

Win Probability: Guardians 55% , White Sox 45%

Final Thoughts

The starting pitching matchup is pretty even according to my models. But the Guardians have advantages just about everywhere else on the field going into this game. I expect the Guardians to bounce back from their setback in the second game of yesterday’s doubleheader. Look for the Guardians to win this game on the road and to have a chance to lock up this series on Sunday before both teams head into the break.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.