Cleveland Guardians vs Chicago White Sox Pick – 7/10/2025

The Cleveland Guardians have an opportunity to turn things around against the lowly Chicago White Sox this week. They have won three straight games over the White Sox this season. Cleveland is favored to win again today in Chicago. Continue reading to get my Guardians vs White Sox prediction as I determine whether or not the Guardians will win a fourth in a row over their division rivals.

Our Guardians vs White Sox Pick

• Pick: Guardians -1.5
• Confidence: 4 stars
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4.8/5

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Game Snapshot

• Matchup: Cleveland Guardians vs Chicago White Sox
• Date & Time: Thursday, July 10, 2025, 7:40 p.m. ET
• Starting Pitchers: Logan Allen vs Jonathan Cannon
• Stadium: Rate Field in Chicago, IL
• Broadcast: CHSN and CLEG

Key Storylines

• Both starting pitchers have losing records going into this game. Logan Allen is 5-7 with a 4.07 ERA. Jonathan Allen is 3-7 and has a 4.50 ERA. They are both allowing a hit per inning or more and will need to be better to prevent their opponent from a big offensive day.
• This is the first game of a four-game series between these teams. This series is very important for Cleveland. They need a strong finish to their first half of the season to go into the second half with some momentum.
• These teams are evenly matched in the bullpen. The Guardians are slightly better in terms of bullpen ERA entering this series.

Betting Trends & H2H

• Last five games: The Guardians are 3-2 and the White Sox are 2-3.
• Day/Night splits: The Guardians have gone 25-30 in their night games this year. Chicago is just 13-31 in night games.
• Cleveland holds a 3-0 lead in the season series between these teams. They outscored the White Sox by a combined score of 10-3 in the first three games these teams played in April.
• Chicago is 30-61 as an underdog so far this season.

Guardians vs White Sox Model Projection

Score Projection: Guardians 5 – White Sox 3

Win Probability: Guardians 62%, White Sox 38%

Final Thoughts

The Guardians have a slight advantage when it comes to their starting pitching and bullpen. They are much better offensively, though, which should make the difference in this game. I recommend laying the runline with the Guardians in this game. Expect them to improve to 4-0 for the season over the White Sox going into the weekend.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.