Cleveland Guardians vs Arizona Diamondbacks Pick – 8/19/2025
The Cleveland Guardians and Arizona Diamondbacks will square off tonight in Phoenix. This is the second game of their three-game interleague series. Cleveland got the win in the series opener on Monday and will look for another win to help their chances in the AL Wild Card race. Here, I’ve taken a closer look at this interleague matchup and you can find my Guardians vs Diamondbacks prediction below.
Our Guardians vs Diamondbacks Pick
- Pick: Guardians Moneyline
- Confidence: 3/5
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Game Snapshot
- Matchup: Cleveland Guardians vs Arizona Diamondbacks
- Date & Time: Tuesday, August 19, 2025, 9:40 PM ET
- Starting Pitchers: Tanner Bibee (CLE) vs Eduardo Rodríguez (ARI)
- Stadium: Chase Field, Phoenix, AZ
- Broadcast: MLB Network
Key Storylines
Pitching matchup
Tanner Bibee is 9-9 with a 4.54 ERA and he will take the mound for Cleveland. Bibee is 5-0 over his last seven starts and he has not taken a loss since before the All-Star break. Eduardo Rodríguez has been a disappointment this year for the Diamondbacks. He is 5-7 with a 5.40 ERA for the year. Rodríguez allowed just one run over seven innings against the Rockies in his last start. But that was against the Rockies and Rodriguez could be in for a tougher day at the office here.
Key Players
- Brayan Rocchio (CLE): Rocchio has struggled for most of this season for the Guardians. But he’s hit home runs in a couple of recent games for Cleveland and will try to stay hot in this matchup.
- Geraldo Perdomo (ARI): Perdomo was the only member of the Diamondbacks to collect multiple hits in Monday’s game. He will be counted on to produce again for the D-Backs in this game.
Recent team streaks
Cleveland snapped a three-game losing streak with their win over the Diamondbacks on Monday night. The Diamondbacks dropped their fourth game in a row when they fell in that contest and they will look to snap their current losing streak tonight.
Best Player Props
| Player | Prop |
|---|---|
| José Ramírez | Over 0.5 Home Runs |
| Ketel Marte | Over 1.5 Total Bases |
| Corbin Carroll | Over 0.5 Stolen Bases |
Betting Trends & H2H
- The Guardians won the lone matchup between these teams this season on Monday.
- Cleveland’s 3-1 win over Arizona last night stayed under the total with some room to spare.
Guardians vs Diamondbacks Model Projection
- Score Projection: Guardians 5 – Diamondbacks 3
- Win Probability: Guardians 52%, Diamondbacks 48%
Final Thoughts
This game is a big opportunity for both of these teams to get an important win as they look to climb closer to Wild Card positioning in their respective leagues. I think Cleveland is in the best position to take advantage of that opportunity. The Guardians are playing better baseball of late and they have a red-hot starting pitcher on the bump in this game. I’ll take the Guardians to win on the road in what should be a good one from Phoenix.
