Cincinnati Reds vs Washington Nationals Pick – 7/21/2025

The Cincinnati Reds and Washington Nationals kick off a three-game series Monday night at Nationals Park. The Reds enter off a series win in Queens against the Mets. They will look to keep inching closer to a Wild Card spot in the National League. Before first pitch from Washington, continue reading to get my analysis for this game and my Reds vs Nationals prediction.

Our Reds vs Nationals Pick

• Pick: Reds moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Cincinnati Reds vs Washington Nationals
• Date & Time: Monday, July 21, 2025, 6:45 p.m. ET
• Starting Pitchers: Brady Singer vs Jake Irvin
• Stadium: Nationals Park, Washington, D.C.
• Broadcast: MASN and FDSOH

Key Storylines

Pitching Form

• Brady Singer: Cincinnati right-hander Brady Singer is 7–7 with a 4.32 ERA on the year. He has issued 40 walks in 100 innings and needs to be better with his control to help the Reds in this game.
• Jake Irvin: Washington’s Jake Irvin is 7–5 and has a 4.58 ERA. Avoiding hard contact is the key to success for Irvin. He has given up 22 home runs in 116 innings this year and faces a lineup with plenty of power here.

Bullpen Usage

• Cincinnati: The Reds will unquestionably have the advantage in the bullpens between these two teams. The Reds have a bullpen ERA of under 4.00 for the year. Their pen helped hold the Mets to just nine runs over three games this past weekend.
• Washington: Washington has the worst bullpen ERA in baseball coming into this series. Their bullpen has an ERA of 5.81 and they will need to be better against the Reds.

Recent Team Streaks

• Reds: Cincinnati has won four of its last five games but did have their recent winning streak snapped by the Mets on Sunday.
• Nationals: The Nationals have lost four of their last five games coming into this National League matchup.

Best Player Props

Betting Trends & H2H

• The Nationals hold a 2-1 edge in the season series between these teams so far.
• Two of the three games between these teams in 2025 went under their totals.
• Cincinnati has been much more effective at covering the runline this season. They have done so in 54% of their games for the year.

Reds vs Nationals Model Projection

Score Projection: Reds 6 – Nationals 4

Win Probability: Reds 55%, Nationals 45%

Final Thoughts

Cincinnati is playing better baseball than the Nationals right now. The Reds are 2.5 games out of the final Wild Card spot in the National League. Here, I expect the Reds to get a win that could pull them closer to a playoff berth depending on how the games in the rest of the NL go. Look for Singer to provide the Reds with an early lead by locking down the Nats’ bats. After that, the bullpen advantage for the Reds will make the difference.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.