Cincinnati Reds vs St. Louis Cardinals Pick – 9/15/2025
The Cincinnati Reds and St. Louis Cardinals will face off in a huge game for the NL Wild Card race on Monday night. The Reds and Cardinals are both still in contention for the final Wild Card spot and starting this series with a win would be huge for either side. Before the action begins in St. Louis, continue reading to get my Reds vs Cardinals prediction for tonight’s game.
Our Reds vs Cardinals Pick
- Pick: Cardinals moneyline
- Confidence: 3/5
- Get Your Bonus Bets: Use BetMGM promo code ATSBONUS to get up to $1,500 in bonus bets if your first bet doesn’t win!
Game Snapshot
- Matchup: Cincinnati Reds vs St. Louis Cardinals
- Date & Time: Monday, September 15, 2025, 7:45 PM ET
- Starting Pitchers: Zack Littell vs Matthew Liberatore
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: MLB.TV
Key Storylines
- The Reds enter this game 2.5 games back of the final Wild Card spot in the NL. The Cardinals are four games back of the final NL Wild Card spot. Both teams need a win here to inch closer to a playoff spot.
- The Reds can get back to the .500 mark for the season with a win tonight. They will need to beat a Cardinals team that they have struggled against at times this season if that is going to happen.
Pitching Matchup
Zack Littell will start this game for the Reds on Monday night. He is 9-8 with a 3.78 ERA for the season. He’s coming off six innings of two-run ball at San Diego on September 9, showing efficient command in that game. The problem for Littell in recent weeks has been susceptibility to the home run and he will need to locate his pitches well to avoid getting hit hard again.
Matthew Liberatore comes into this start at 7-12 with a 4.35 ERA for the Cardinals. His fastball-curve mix plays when he gets ahead, but he can be vulnerable when behind in counts. Cincinnati’s approach against lefties will determine whether he settles in or faces early traffic on the bases.
Recent Team Streaks
- The Reds have lost three straight games going into this contest. They were swept by the Athletics in their last series.
- St. Louis dropped two out of three against the Milwaukee Brewers in their last series, but they won the final game of that series on Sunday.
Best Player Props
| Prop Type | Player | Suggested Line |
|---|---|---|
| Strikeouts | Zack Littell | Over 4.5 |
| Strikeouts | Matthew Liberatore | Over 4.5 |
| Total Bases | Elly De La Cruz | Over 1.5 |
| Total Bases | Alec Burleson | Over 1.5 |
Betting Trends & H2H
- The Cardinals hold a 6-4 lead in the season series against the Reds in 2025.
- This game is the start of the final series of the year between these NL Central rivals.
Reds vs Cardinals Model Projection
Score Projection: Reds 5 – Cardinals 6
Win Probability: Reds 48%, Cardinals 52%
Final Thoughts
The margins in this game are going to be incredibly slim. But I think that the home team is the best bet for this matchup. I’ll take the Cardinals to win at home against a Reds team that is coming off a sweep at the hands of one of the worst team in baseball.
